Nascent Transcriptomics Reveal Cellular Prolytic Factors Upregulated Upstream of the Latent-to-Lytic Switch Protein of Epstein-Barr Virus
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DOI: 10.1128/jvi.01966-19
Abstract: Transition from latency to the lytic phase is necessary for herpesvirus-mediated pathology as well as viral spread and persistence in the population at large. Yet, viral genomes in only some cells in a population of… read more here.
Keywords: barr virus; latent lytic; epstein barr; virus ... See more keywords
CRISPR Interference Efficiently Silences Latent and Lytic Viral Genes in Kaposi’s Sarcoma-Associated Herpesvirus-Infected Cells
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DOI: 10.3390/v13050783
Abstract: Uncovering viral gene functions requires the modulation of gene expression through overexpression or loss-of-function. CRISPR interference (CRISPRi), a modification of the CRISPR-Cas9 gene editing technology, allows specific and efficient transcriptional silencing without genetic ablation. CRISPRi… read more here.
Keywords: crispr interference; kaposi sarcoma; sarcoma associated; lytic viral ... See more keywords