Targeting the Latent Reservoir for HIV‐1
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.04.030
Abstract: &NA; Antiretroviral therapy can effectively block HIV‐1 replication and prevent or reverse immunodeficiency in HIV‐1‐infected individuals. However, viral replication resumes within weeks of treatment interruption. The major barrier to a cure is a small pool… read more here.
Keywords: reservoir hiv; reservoir; hiv; cure ... See more keywords
Bayesian phylogenetic inference of HIV latent lineage ages using serial sequences
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2023.0022
Abstract: HIV evolves rapidly within individuals, allowing phylogenetic studies to infer the history of viral lineages on short time scales. Latent HIV sequences are an exception to this rapid evolution, as their transcriptional inactivity leads to… read more here.
Keywords: latent hiv; hiv; latent reservoir; method ... See more keywords
Insights into the HIV-1 Latent Reservoir and Strategies to Cure HIV-1 Infection
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/6952286
Abstract: Since the first discovery of human immunodeficiency virus 1 (HIV-1) in 1983, the targeted treatment, antiretroviral therapy (ART), has effectively limited the detected plasma viremia below a very low level and the technique has been… read more here.
Keywords: hiv; infection; latent reservoir; cure hiv ... See more keywords
Effect of the Latent Reservoir on the Evolution of HIV at the Within- and Between-Host Levels
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DOI: 10.1371/journal.pcbi.1005228
Abstract: The existence of long-lived reservoirs of latently infected CD4+ T cells is the major barrier to curing HIV, and has been extensively studied in this light. However, the effect of these reservoirs on the evolutionary… read more here.
Keywords: hiv; within host; effect; latent reservoir ... See more keywords
Pre-existing resistance in the latent reservoir can compromise VRC01 therapy during chronic HIV-1 infection
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008434
Abstract: Passive immunization with broadly neutralizing antibodies (bNAbs) of HIV-1 appears a promising strategy for eliciting long-term HIV-1 remission. When administered concomitantly with the cessation of antiretroviral therapy (ART) to patients with established viremic control, bNAb… read more here.
Keywords: hiv; latent reservoir; resistance; therapy ... See more keywords
Efficacy of the Post-Exposure Prophylaxis and of the HIV Latent Reservoir in HIV Infection
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DOI: 10.3390/math7060515
Abstract: We propose a fractional order model to study the efficacy of the Post-Exposure Prophylaxis (PEP) in human immunodeficiency virus (HIV) within-host dynamics, in the presence of the HIV latent reservoir. Latent reservoirs harbor infected cells… read more here.
Keywords: latent reservoir; efficacy post; hiv; latent ... See more keywords