Adipose-Derived Stem Cells Ameliorate Experimental Murine Colitis via TSP-1-Dependent Activation of Latent TGF-β
Sign Up to like & getrecommendations! Published in 2017 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-017-4578-y
Abstract: BackgroundAdipose tissue-derived stem cells (ASCs) have been investigated as therapeutic tools for a variety of autoimmune diseases, including inflammatory diseases. However, the mechanisms underlying the immunomodulatory properties of ASCs are not well understood. Here, we… read more here.
Keywords: latent tgf; activation latent; ascs; colitis ... See more keywords
The dynamics of TGF-β in dental pulp, odontoblasts and dentin
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22823-7
Abstract: Transforming growth factor-beta (TGF-β) is critical for cell proliferation and differentiation in dental pulp. Here, we show the dynamic mechanisms of TGF-β in porcine dental pulp, odontoblasts and dentin. The mRNA of latent TGF-β1 and… read more here.
Keywords: latent tgf; dental pulp; pulp odontoblasts; odontoblasts dentin ... See more keywords
Combined targeting of soluble latent TGF-ß and a solid tumor-associated antigen with adapter CAR T cells
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2140534
Abstract: ABSTRACT Solid tumors consist of malignant and nonmalignant cells that together create the local tumor microenvironment (TME). Additionally, the TME is characterized by the expression of numerous soluble factors such as TGF-β. TGF-β plays an… read more here.
Keywords: tumor; latent tgf; car; tgf ... See more keywords
Phenytoin induces connective tissue growth factor (CTGF/CCN2) production through NADPH oxidase 4-mediated latent TGFβ1 activation in human gingiva fibroblasts: Suppression by curcumin.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of periodontal research"
DOI: 10.1111/jre.13058
Abstract: OBJECTIVE AND BACKGROUND Gingival overgrowth (GO) is a common side effect of some drugs such as anticonvulsants, immunosuppressant, and calcium channel blockers. Among them, the antiepileptic agent phenytoin is the most common agent related to… read more here.
Keywords: ccn2 synthesis; phenytoin; latent tgf; tgf activation ... See more keywords
Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aau2909
Abstract: Visualizing TGF-β1 regulation by GARP Regulatory T cells (Tregs) can suppress immune responses through a variety of mechanisms. One such mechanism involves the activation of a surface-bound latent form of the cytokine transforming growth factor–β1… read more here.
Keywords: latent tgf; garp; antibody; regulatory cells ... See more keywords
Hepsin regulates TGFβ signaling via fibronectin proteolysis.
Sign Up to like & getrecommendations! Published in 2021 at "EMBO reports"
DOI: 10.15252/embr.202152532
Abstract: Transforming growth factor-beta (TGFβ) is a multifunctional cytokine with a well-established role in mammary gland development and both oncogenic and tumor-suppressive functions. The extracellular matrix (ECM) indirectly regulates TGFβ activity by acting as a storage… read more here.
Keywords: latent tgf; tgf; regulates tgf; hepsin regulates ... See more keywords
Latent TGF-β Activation Is a Hallmark of the Tenascin Family
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.613438
Abstract: Transforming growth factor-β (TGF-β) isoforms are secreted as inactive complexes formed through non-covalent interactions between bioactive TGF-β entities and their N-terminal pro-domains called latency-associated peptides (LAP). Extracellular activation of latent TGF-β within this complex is… read more here.
Keywords: tgf; tenascin family; latent tgf; activation ... See more keywords
Fructose Induces Pulmonary Fibrotic Phenotype Through Promoting Epithelial-Mesenchymal Transition Mediated by ROS-Activated Latent TGF-β1
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.850689
Abstract: Fructose is a commonly used food additive and has many adverse effects on human health, but it is unclear whether fructose impacts pulmonary fibrosis. TGF-β1, a potent fibrotic inducer, is produced as latent complexes by… read more here.
Keywords: phenotype; latent tgf; fibrotic phenotype; lung epithelial ... See more keywords