Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor.
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00012
Abstract: We have previously reported gnidimacrin (GM), a protein kinase C (PKC) agonist, significantly reduces the frequency of HIV-1 latently infected cells in peripheral blood mononuclear cells (PBMCs) from patients undergoing successful antiretroviral therapy at low… read more here.
Keywords: inhibitor; hiv; hiv latently; latently infected ... See more keywords
Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14321
Abstract: Reactivation of human cytomegalovirus (HCMV) in transplant recipients can cause life-threatening disease. Consequently, for transplant recipients, killing latently infected cells could have far-reaching clinical benefits. In vivo, myeloid cells and their progenitors are an important… read more here.
Keywords: protein; latently infected; infected cells; fusion toxin ... See more keywords
Analysis of HIV latent infection model with multiple infection stages and different drug classes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biological Dynamics"
DOI: 10.1080/17513758.2022.2113828
Abstract: Latently infected CD T cells represent one of the major obstacles to HIV eradication even after receiving prolonged highly active anti-retroviral therapy (HAART). Long-term use of HAART causes the emergence of drug-resistant virus which is… read more here.
Keywords: hiv; infected cells; infection; latently infected ... See more keywords
54 Impact of Carbon Nanoparticle–Triggered Gammaherpesvirus Reactivation on Lung Immunity and Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Work Exposures and Health"
DOI: 10.1093/annweh/wxac087.224
Abstract: Inhalation of environmental particles and herpesvirus infection are ubiquitous in our society. Herpesviruses persist lifelong in the host in a latent state, which can be exited by stress-induced reactivation with production of lytic virus. Our… read more here.
Keywords: carbon; damage; reactivation; lung ... See more keywords
Stacking the odds: Multiple sites for HSV-1 latency
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf4904
Abstract: A hallmark of herpes simplex virus (HSV) infection is the establishment of latent virus in peripheral sensory ganglia of the latently infected host. We and others originally reported that the latency-associated transcript (LAT) is the… read more here.
Keywords: odds multiple; multiple sites; stacking odds; latency ... See more keywords
Establishment of a Novel Humanized Mouse Model To Investigate In Vivo Activation and Depletion of Patient-Derived HIV Latent Reservoirs
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.02051-18
Abstract: Sustained remission of HIV infection is prevented by a persistent reservoir of latently infected cells capable of reinitiating systemic infection and viremia. To evaluate strategies to reactivate and deplete this reservoir, we developed and characterized… read more here.
Keywords: hiv; mouse model; infection; latently infected ... See more keywords
Single-Cell Profiling of Latently SIV-Infected CD4+ T Cells Directly Ex Vivo to Reveal Host Factors Supporting Reservoir Persistence
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00604-22
Abstract: Effective combination antiretroviral therapy controls HIV-1 infection but fails to eliminate latent viral reservoirs that give rise to viremia upon treatment interruption. Strategies to eradicate latently infected cells require a better understanding of their biology… read more here.
Keywords: cell; cd4 cells; infected cells; infection ... See more keywords
Replication competence of virions induced from CD4+ lymphocytes latently infected with HIV
Sign Up to like & getrecommendations! Published in 2019 at "Retrovirology"
DOI: 10.1186/s12977-019-0466-1
Abstract: Latently infected CD4 lymphocytes preclude cure of HIV infection, even with the most effective antiretroviral therapy. The replication competent latent HIV reservoir has been quantified with the terminal dilution quantitative viral outgrowth assay, which induces… read more here.
Keywords: cd4 lymphocytes; hiv; replication competence; replication competent ... See more keywords
Brain HIV-1 latently-infected reservoirs targeted by the suicide gene strategy
Sign Up to like & getrecommendations! Published in 2021 at "Virology Journal"
DOI: 10.1186/s12985-021-01584-2
Abstract: Reducing the pool of HIV-1 reservoirs in patients is a must to achieve functional cure. The most prominent HIV-1 cell reservoirs are resting CD4 + T cells and brain derived microglial cells. Infected microglial cells are believed… read more here.
Keywords: hiv; brain; strategy; gene ... See more keywords
Detection of Chimeric Cellular: HIV mRNAs Generated Through Aberrant Splicing in HIV-1 Latently Infected Resting CD4+ T Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.855290
Abstract: Latent HIV-1 provirus in infected individuals on suppressive therapy does not always remain transcriptionally silent. Both HIV-1 LTR and human gene promoter derived transcriptional events can contribute HIV-1 sequences to the mRNA produced in the… read more here.
Keywords: hiv; aberrant splicing; chimeric cellular; cellular hiv ... See more keywords