Imipramine ameliorates early life stress-induced alterations in synaptic plasticity in the rat lateral amygdala
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2016.09.065
Abstract: HighlightsMaternal separation stress reduced both LTP and LTD at the thalamic input to the lateral amygdala.Maternal separation stress impaired LTP and enhanced LTD at the cortical input to the lateral amygdala.Treatment with imipramine restored the… read more here.
Keywords: lateral amygdala; input; stress; synaptic plasticity ... See more keywords
αCaMKII in the lateral amygdala mediates PTSD-Like behaviors and NMDAR-Dependent LTD
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2021.100359
Abstract: Post-traumatic stress disorder (PTSD) is a psychiatric disorder that afflicts many individuals. However, its molecular and cellular mechanisms remain largely unexplored. Here, we found PTSD susceptible mice exhibited significant up-regulation of alpha-Ca2+/calmodulin-dependent kinase II (αCaMKII)… read more here.
Keywords: lateral amygdala; ltd; like behaviors; camkii ... See more keywords
Associative and plastic thalamic signaling to the lateral amygdala controls fear behavior
Sign Up to like & getrecommendations! Published in 2020 at "Nature Neuroscience"
DOI: 10.1038/s41593-020-0620-z
Abstract: Decades of research support the idea that associations between a conditioned stimulus (CS) and an unconditioned stimulus (US) are encoded in the lateral amygdala (LA) during fear learning. However, direct proof for the sources of… read more here.
Keywords: plastic thalamic; associative plastic; lateral amygdala; calr neurons ... See more keywords
Role of lateral amygdala calstabin2 in regulation of fear memory
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Brain"
DOI: 10.1186/s13041-020-00576-7
Abstract: Calstabin2, also named FK506 binding protein 12.6 (FKBP12.6), is a subunit of ryanodine receptor subtype 2 (RyR2) macromolecular complex, an intracellular calcium channel. Studies from our and other’s lab have shown that hippocampal calstabin2 regulates… read more here.
Keywords: lateral amygdala; fear memory; role; calstabin2 ... See more keywords
High frequency optogenetic activation of inputs to the lateral amygdala forms distant association with foot-shock
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Brain"
DOI: 10.1186/s13041-020-00587-4
Abstract: Aim A hallmark of classical conditioning is that conditioned stimulus (CS) must be tightly coupled with unconditioned stimulus (US), often requiring temporal overlap between the two, or a short gap of several seconds. In this… read more here.
Keywords: lateral amygdala; frequency; association; foot shock ... See more keywords
TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.47106
Abstract: TMEM16B (ANO2) is the Ca2+-activated chloride channel expressed in multiple brain regions, including the amygdala. Here we report that Ano2 knockout mice exhibit impaired anxiety-related behaviors and context-independent fear memory, thus implicating TMEM16B in anxiety… read more here.
Keywords: lateral amygdala; amygdala; tmem16b regulates; anxiety related ... See more keywords