Behavior: Local Lateral Habenula Interneurons Mediate Aggression
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2020.06.065
Abstract: A recent study has shown that local inhibitory GAD2-positive neurons regulate the activity of lateral habenula neurons, thereby governing aggressive behavior in male mice. read more here.
Keywords: behavior local; habenula; habenula interneurons; local lateral ... See more keywords
Hypoactivity of the lateral habenula contributes to negative symptoms and cognitive dysfunction of schizophrenia in rats
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2019.05.005
Abstract: Dopaminergic (DAergic) hypofunction in the medial prefrontal cortex (mPFC) has been implicated in the negative and cognitive symptoms of schizophrenia and is regulated by serotonergic (5-HTergic) neurons in the dorsal raphe nucleus (DRN). The lateral… read more here.
Keywords: schizophrenia; negative cognitive; mpfc; symptoms schizophrenia ... See more keywords
Neuronal adaptations in the lateral habenula during drug withdrawal: Preclinical evidence for addiction therapy
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108617
Abstract: The epithalamic lateral habenula (LHb) regulates monoaminergic systems and contributes to the expression of both appetitive and aversive behaviours. Over the past years, the LHb has emerged as a vulnerable brain structure in mental illnesses… read more here.
Keywords: addiction; evidence; drug; drug withdrawal ... See more keywords
Actions of Neuropeptide Y on Synaptic Transmission in the Lateral Habenula
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.04.053
Abstract: Neuropeptide Y is a peptide neuromodulator with protective roles including anxiolytic and antidepressant-like effects in animal models of depression and post-traumatic stress disorder. The lateral habenula (LHb) is a brain region that encodes aversive information… read more here.
Keywords: lhb neurons; transmission; lhb; synaptic transmission ... See more keywords
Engagement of the Lateral Habenula in the Association of a Conditioned Stimulus with the Absence of an Unconditioned Stimulus
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.07.031
Abstract: Neurons in the lateral habenula (LHb) are activated by reward omission and inhibited by reward delivery-reward processing functions opposite those of midbrain dopaminergic neurons. To further explore this, we examined the role of the LHb… read more here.
Keywords: absence; conditioned stimulus; absence unconditioned; group ... See more keywords
Control of behavioral flexibility by the lateral habenula
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2017.07.012
Abstract: Abstract The ability to rapidly switch behaviors in dynamic environments is fundamental to survival across species. Recognizing when an ongoing behavioral strategy should be replaced by an alternative one requires the integration of a diverse… read more here.
Keywords: strategy; trial; behavioral flexibility; lateral habenula ... See more keywords
The Lateral Habenula and Adaptive Behaviors
Sign Up to like & getrecommendations! Published in 2017 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2017.06.001
Abstract: The evolutionarily conserved lateral habenula (LHb) enables dynamic responses to continually changing contexts and environmental conditions. A model is proposed to account for greater mnemonic and contextual control over LHb-mediated response flexibility as vertebrate brains… read more here.
Keywords: response; lhb; habenula; habenula adaptive ... See more keywords
Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2020.100267
Abstract: The lateral habenula (LHb) is an epithalamic brain region associated with value-based decision making and stress evasion through its modulation of dopamine (DA)-mediated reward circuitry. Specifically, increased activity of the LHb is associated with drug… read more here.
Keywords: early life; stress; excitability; lateral habenula ... See more keywords
Stress induces divergent gene expression among lateral habenula efferent pathways
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2020.100268
Abstract: The lateral habenula (LHb) integrates critical information regarding aversive stimuli that shapes decision making and behavioral responses. The three major LHb outputs innervate dorsal raphe nucleus (DRN), ventral tegmental area (VTA), and the rostromedial tegmental… read more here.
Keywords: lhb neurons; gene expression; stress; expression ... See more keywords
Lateral hypothalamus orexinergic inputs to lateral habenula modulate maladaptation after social defeat stress
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2021.100298
Abstract: Social stress, a common stressor, causes multiple forms of physical and mental dysfunction. Prolonged exposure to social stress is associated with a higher risk of psychological disorders, including anxiety disorders and major depressive disorder (MDD).… read more here.
Keywords: social defeat; chronic social; lateral habenula; defeat stress ... See more keywords
Lateral Habenula and Its Potential Roles in Pain and Related Behaviors.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00067
Abstract: The lateral habenula (LHb) is a tiny structure that acts as a hub, relaying signals from the limbic forebrain structures and basal ganglia to the brainstem modulatory area. Facilitated by updated knowledge and more precise… read more here.
Keywords: lateral habenula; roles pain; habenula potential; related behaviors ... See more keywords