Corticotropin-releasing factor neurotransmission in the lateral hypothalamus modulates the tachycardiac response during acute emotional stress in rats
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.11.010
Abstract: The lateral hypothalamus (LH) is implicated in the physiological and behavioral responses during stressful events. However, the local neurochemical mechanisms related to control of stress responses by this hypothalamic area are not completely understood. Therefore,… read more here.
Keywords: stress rats; skin temperature; stress; neurotransmission ... See more keywords
Energy Balance: Lateral Hypothalamus Hoards Food Memories
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.06.082
Abstract: The lateral hypothalamus is known to drive food consumption during periods of hunger. A new study suggests that the lateral hypothalamus may also participate in the formation and storage of memories about events in the… read more here.
Keywords: hypothalamus hoards; hypothalamus; energy balance; lateral hypothalamus ... See more keywords
Glutamatergic lateral hypothalamus promotes defensive behaviors
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108239
Abstract: The glutamatergic lateral hypothalamus (LH) has been implicated in a variety of behaviors, such as evasion and feeding, while its role in defensive behaviors and relevant neurocircuits remains unclear. Here, we demonstrate that glutamatergic LH… read more here.
Keywords: glutamatergic; glutamatergic neurons; glutamatergic lateral; defensive behaviors ... See more keywords
Reversible inactivation of the lateral hypothalamus reversed high reward choices in cost-benefit decision-making in rats
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2017.10.001
Abstract: HighlightsLH inactivation changed the preference in effort‐based decision making.LH inactivation changed the preference in delay‐based decision making.LH inactivation increased total latency for making a decision.LH inactivation decreased spontaneous locomotors activities. ABSTRACT The Lateral hypothalamus (LH)… read more here.
Keywords: decision; based decision; inactivation; decision making ... See more keywords
PARALLEL CIRCUITS FROM THE BED NUCLEI OF STRIA TERMINALIS TO THE LATERAL HYPOTHALAMUS DRIVE OPPOSING EMOTIONAL STATES
Sign Up to like & getrecommendations! Published in 2018 at "Nature neuroscience"
DOI: 10.1038/s41593-018-0198-x
Abstract: Lateral hypothalamus (LH) neurons containing the neuropeptide hypocretin (HCRT; orexin) modulate affective components of arousal, but their relevant synaptic inputs remain poorly defined. Here we identified inputs onto LH neurons that originate from neuronal populations… read more here.
Keywords: emotional states; hypothalamus; bed nuclei; lateral hypothalamus ... See more keywords
GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43580-1
Abstract: Olfaction guides goal-directed behaviours including feeding. To investigate how central olfactory neural circuits control feeding behaviour in mice, we performed retrograde tracing from the lateral hypothalamus (LH), an important feeding centre. We observed a cluster… read more here.
Keywords: olfactory cortex; projection neurons; neurons olfactory; mice ... See more keywords
Orexin-2 receptor antagonism in the cornu ammonis 1 region of hippocampus prevented the antinociceptive responses induced by chemical stimulation of the lateral hypothalamus in the animal model of persistent pain
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000646
Abstract: Supplemental Digital Content is available in the text. Orexins are excitatory neuropeptides, mainly produced by neurons located in the lateral hypothalamus, which project to many brain areas. The orexinergic system plays a fundamental role in… read more here.
Keywords: pain; chemical stimulation; lateral hypothalamus; hypothalamus ... See more keywords
Mu opioid receptor signaling in the nucleus accumbens shell increases responsiveness of satiety‐modulated lateral hypothalamus neurons
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.13579
Abstract: Opioid signaling in the nucleus accumbens shell (sNAcc) has been implicated in hedonic feeding and binge eating behavior. The sNAcc projects to the lateral hypothalamus (LH), and this pathway has been suggested to modulate palatability‐driven… read more here.
Keywords: accumbens shell; infusion; signaling nucleus; satiety ... See more keywords
The dual orexin receptor antagonist, DORA‐22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14055
Abstract: Chronic insomnia is defined as a persistent difficulty with sleep initiation maintenance or non‐restorative sleep. The therapeutic standard of care for this condition is treatment with gamma‐aminobutyric acid (GABA)A receptor modulators, which promote sleep but… read more here.
Keywords: dual orexin; receptor; hypothalamus prefrontal; lateral hypothalamus ... See more keywords
ATP in the lateral hypothalamus/perifornical area enhances the CO2 chemoreflex control of breathing
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Physiology"
DOI: 10.1113/ep087182
Abstract: What is the central question of this study? ATP is known to modulate the chemosensitivity of some brain areas. However, whether the ATP contributes specifically to the mechanism of chemoreception in the lateral hypothalamus/perifornical area… read more here.
Keywords: perifornical area; hypothalamus perifornical; lateral hypothalamus; atp lateral ... See more keywords
Glutamatergic neurons in lateral hypothalamus play a vital role in acupuncture preconditioning to alleviate MIRI.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurophysiology"
DOI: 10.1152/jn.00424.2022
Abstract: Myocardial ischemia-reperfusion injury (MIRI) has high morbidity and mortality worldwide. Increasing evidence has shown that electro-acupuncture (EA) plays a critical role in alleviating MIRI. The aim of this study is to investigate whether glutamatergic neurons… read more here.
Keywords: lateral hypothalamus; acupuncture; role; miri ... See more keywords