A selective serotonin reuptake inhibitor ameliorates obsessive–compulsive disorder-like perseverative behavior by attenuating 5-HT2C receptor signaling in the orbitofrontal cortex
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108926
Abstract: Perseveration is a characteristic of patients with obsessive-compulsive disorder (OCD). Clinically, neuronal activity in the lateral orbitofrontal cortex (OFC) is increased in OCD patients. Successful treatment with selective serotonin reuptake inhibitors (SSRIs) reduces activity in… read more here.
Keywords: compulsive disorder; obsessive compulsive; orbitofrontal cortex; lateral ofc ... See more keywords
Performance in delayed non-matching to sample task predicts the diagnosis of obsessive–compulsive disorder
Sign Up to like & getrecommendations! Published in 2019 at "Translational Psychiatry"
DOI: 10.1038/s41398-019-0667-3
Abstract: Electrical stimulation studies have recently evidenced the involvement of orbitofrontal cortex (OFC) in obsessive–compulsive disorder (OCD). In addition, lateral OFC is activated in healthy subjects during delayed non-matching-to-sample task (DNMS). In the present study, we… read more here.
Keywords: task; compulsive disorder; obsessive compulsive; ocd patients ... See more keywords
Value-guided remapping of sensory cortex by lateral orbitofrontal cortex.
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DOI: 10.1038/s41586-020-2704-z
Abstract: Adaptive behaviour crucially depends on flexible decision-making, which in mammals relies on the frontal cortex, specifically the orbitofrontal cortex (OFC)1-9. How OFC encodes decision variables and instructs sensory areas to guide adaptive behaviour are key… read more here.
Keywords: cortex; sensory cortex; lateral ofc; value ... See more keywords
Damage to Orbitofrontal Areas 12 and 13, but Not Area 14, Results in Blunted Attention and Arousal to Socioemotional Stimuli in Rhesus Macaques
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2020.00150
Abstract: An earlier study in monkeys indicated that lesions to the mid-portion of the ventral orbitofrontal cortex (OFC), including Walker’s areas 11 and 13 (OFC11/13), altered the spontaneous scanning of still pictures of primate faces (neutral… read more here.
Keywords: attention arousal; lateral ofc; area; rhesus macaques ... See more keywords