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1
Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.3282
Abstract: Importance Clinical trial activity in amyotrophic lateral sclerosis (ALS) is dramatically increasing; as a result, trial modifications have been introduced to improve efficiency, outcome measures have been reassessed, and considerable discussion about the level of…
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Keywords:
lateral sclerosis;
end points;
primary outcome;
amyotrophic lateral ... See more keywords
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2
Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51501
Abstract: The Faroese population isolate harbors epidemiological and genetic characteristics that likely differ from outbred populations. This population‐based register study found that the Faroese 2010–2020 crude incidence of amyotrophic lateral sclerosis (ALS) was 4.9/100,000 person‐years (95% confidence…
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Keywords:
incidence;
incidence amyotrophic;
lateral sclerosis;
2010 2020 ... See more keywords
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1
Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51580
Abstract: Metabolic dysfunction has been suggested to be involved in the pathophysiology of amyotrophic lateral sclerosis (ALS). This study aimed to investigate the potential role of metabolic biomarkers in the progression of ALS and understand the…
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Keywords:
lateral sclerosis;
potential role;
metabolic biomarkers;
amyotrophic lateral ... See more keywords
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1
Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51660
Abstract: This research aims to examine the impact of the National Amyotrophic Lateral Sclerosis (ALS) Registry‐funded research activities.
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Keywords:
lateral sclerosis;
registry;
national amyotrophic;
research ... See more keywords
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Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51663
Abstract: To investigate intercultural neurologists' perception of well‐being in patients with amyotrophic lateral sclerosis (ALS) using gastrostomy (PEG), non‐invasive, and/or invasive ventilation (NIV/IV) and to analyse the determinants and impact on the management of the above…
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Keywords:
techniques amyotrophic;
supportive techniques;
lateral sclerosis;
well supportive ... See more keywords
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1
Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51673
Abstract: HTT full‐penetrance pathogenic repeat expansions, the genetic cause of Huntington's disease (HD), have been recently reported in a minority of frontotemporal dementia/amyotrophic lateral sclerosis (ALS) patients (0.13%). We analyzed HTT CAG repeats in an Italian…
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Keywords:
htt cag;
repeat;
lateral sclerosis;
cag ... See more keywords
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2
Published in 2023 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51712
Abstract: Spinal cord degeneration is a hallmark of amyotrophic lateral sclerosis. The assessment of gray matter and white matter cervical spinal cord atrophy across clinical stages defined using the King's staging system could advance the understanding…
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Keywords:
amyotrophic lateral;
lateral sclerosis;
cervical spinal;
spinal cord ... See more keywords
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2
Published in 2023 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.51821
Abstract: OBJECTIVE No efficacious treatments exist to improve or prolong bulbar functions of speech and swallowing in persons with amyotrophic lateral sclerosis (pALS). This study evaluated the short-term impact of dextromethorphan/quinidine (DMQ) treatment on speech and…
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Keywords:
bulbar;
dextromethorphan quinidine;
lateral sclerosis;
dmq ... See more keywords
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Published in 2018 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.565
Abstract: Noninvasive tests to diagnose and monitor the progression of neurodegenerative disorders have been a challenge for decades. The aim of this study was to explore the feasibility of applying liquid biopsy procedures to patients with…
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Keywords:
source;
biopsy new;
liquid biopsy;
amyotrophic lateral ... See more keywords
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Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.721
Abstract: Physiological changes potentially influence disease progression and survival along the Amyotrophic Lateral Sclerosis (ALS)‐Frontotemporal dementia (FTD) spectrum. The peripheral peptides that regulate eating and metabolism may provide diagnostic, metabolic, and progression biomarkers. The current study…
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Keywords:
amyotrophic lateral;
frontotemporal dementia;
eating peptides;
lateral sclerosis ... See more keywords
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Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25468
Abstract: Identifying mechanisms of neurodegenerative disease causation has long seemed to be beyond the reach of traditional epidemiological tools. Elucidating a plausible mechanism for initiation of amyotrophic lateral sclerosis (ALS) has appeared particularly elusive. The impression…
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Keywords:
cholesterol levels;
ldl;
cholesterol;
amyotrophic lateral ... See more keywords