Tetramethylpyrazine Nitrone in Amyotrophic Lateral Sclerosis
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DOI: 10.1001/jamanetworkopen.2024.61055
Abstract: Key Points Question Is treatment with tetramethylpyrazine nitrone (TBN) safe and effective for improving functional outcomes in patients with amyotrophic lateral sclerosis (ALS)? Findings In this randomized clinical trial of 155 patients who were given… read more here.
Keywords: amyotrophic lateral; tetramethylpyrazine nitrone; lateral sclerosis; tetramethylpyrazine ... See more keywords
Use of Common Psychiatric Medications and Risk and Prognosis of Amyotrophic Lateral Sclerosis
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DOI: 10.1001/jamanetworkopen.2025.14437
Abstract: Key Points Question Is there an association between prescribed use of common psychiatric medications and the risk and progression of amyotrophic lateral sclerosis (ALS)? Findings In this case-control study including nearly 9000 individuals, prescribed use… read more here.
Keywords: common psychiatric; medications risk; use common; amyotrophic lateral ... See more keywords
Amyotrophic Lateral Sclerosis Clinical Trials and Interpretation of Functional End Points and Fluid Biomarkers: A Review.
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DOI: 10.1001/jamaneurol.2022.3282
Abstract: Importance Clinical trial activity in amyotrophic lateral sclerosis (ALS) is dramatically increasing; as a result, trial modifications have been introduced to improve efficiency, outcome measures have been reassessed, and considerable discussion about the level of… read more here.
Keywords: lateral sclerosis; end points; primary outcome; amyotrophic lateral ... See more keywords
Verdiperstat in Amyotrophic Lateral Sclerosis
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DOI: 10.1001/jamaneurol.2024.5249
Abstract: This randomized clinical trial investigated the effect of verdiperstat, a myeloperoxidase inhibitor, in amyotrophic lateral sclerosis. read more here.
Keywords: amyotrophic lateral; verdiperstat amyotrophic; neurology; lateral sclerosis ... See more keywords
Reldesemtiv in Amyotrophic Lateral Sclerosis
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DOI: 10.1001/jamaneurol.2025.0241
Abstract: This randomized clinical trial investigates if reldesemtiv slows disease progression in amyotrophic lateral sclerosis. read more here.
Keywords: amyotrophic lateral; neurology; lateral sclerosis; reldesemtiv amyotrophic ... See more keywords
High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010–2020
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DOI: 10.1002/acn3.51501
Abstract: The Faroese population isolate harbors epidemiological and genetic characteristics that likely differ from outbred populations. This population‐based register study found that the Faroese 2010–2020 crude incidence of amyotrophic lateral sclerosis (ALS) was 4.9/100,000 person‐years (95% confidence… read more here.
Keywords: incidence; incidence amyotrophic; lateral sclerosis; 2010 2020 ... See more keywords
Alterations in metabolic biomarkers and their potential role in amyotrophic lateral sclerosis
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DOI: 10.1002/acn3.51580
Abstract: Metabolic dysfunction has been suggested to be involved in the pathophysiology of amyotrophic lateral sclerosis (ALS). This study aimed to investigate the potential role of metabolic biomarkers in the progression of ALS and understand the… read more here.
Keywords: lateral sclerosis; potential role; metabolic biomarkers; amyotrophic lateral ... See more keywords
Impact of the National Amyotrophic Lateral Sclerosis Registry: Analysis of Registry‐funded Research
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DOI: 10.1002/acn3.51660
Abstract: This research aims to examine the impact of the National Amyotrophic Lateral Sclerosis (ALS) Registry‐funded research activities. read more here.
Keywords: lateral sclerosis; registry; national amyotrophic; research ... See more keywords
Well‐being on supportive techniques in amyotrophic lateral sclerosis: from neurologists' perspective
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DOI: 10.1002/acn3.51663
Abstract: To investigate intercultural neurologists' perception of well‐being in patients with amyotrophic lateral sclerosis (ALS) using gastrostomy (PEG), non‐invasive, and/or invasive ventilation (NIV/IV) and to analyse the determinants and impact on the management of the above… read more here.
Keywords: techniques amyotrophic; supportive techniques; lateral sclerosis; well supportive ... See more keywords
Analysis of HTT CAG repeat expansion in Italian patients with amyotrophic lateral sclerosis
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DOI: 10.1002/acn3.51673
Abstract: HTT full‐penetrance pathogenic repeat expansions, the genetic cause of Huntington's disease (HD), have been recently reported in a minority of frontotemporal dementia/amyotrophic lateral sclerosis (ALS) patients (0.13%). We analyzed HTT CAG repeats in an Italian… read more here.
Keywords: htt cag; repeat; lateral sclerosis; cag ... See more keywords
Cervical spinal cord atrophy in amyotrophic lateral sclerosis across disease stages
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DOI: 10.1002/acn3.51712
Abstract: Spinal cord degeneration is a hallmark of amyotrophic lateral sclerosis. The assessment of gray matter and white matter cervical spinal cord atrophy across clinical stages defined using the King's staging system could advance the understanding… read more here.
Keywords: amyotrophic lateral; lateral sclerosis; cervical spinal; spinal cord ... See more keywords