The role of the lateral septum in neuropsychiatric disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25052
Abstract: The lateral septum (LS) is a structure in the midline of the brain that is interconnected with areas associated with stress and feeding. This review highlights the role of the LS in anxiety, depression, and… read more here.
Keywords: septum; septum neuropsychiatric; neuropsychiatric disease; role lateral ... See more keywords
A ventral hippocampal-lateral septum pathway regulates social novelty preference
Sign Up to like & getrecommendations! Published in 2024 at "eLife"
DOI: 10.1101/2024.02.28.582638
Abstract: The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability to recognize kin and familiar individuals and engage in appropriate behaviors is associated with… read more here.
Keywords: hippocampal lateral; social novelty; ventral hippocampal; pathway ... See more keywords
Anorectic and anxiogenic actions of cocaine‐ and amphetamine‐regulated transcript in the lateral septum
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.70055
Abstract: Cocaine‐ and amphetamine‐regulated transcript (CART) is produced in several brain regions including the hypothalamus where it is made in cells that also produce melanin‐concentrating hormone (MCH). CART‐expressing MCH cells densely innervate the lateral septum (LS),… read more here.
Keywords: regulated transcript; cart; cocaine amphetamine; amphetamine regulated ... See more keywords
Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways
Sign Up to like & getrecommendations! Published in 2021 at "eNeuro"
DOI: 10.1523/eneuro.0315-21.2021
Abstract: Abstract The lateral septum (LS) is implicated as a hub that regulates a variety of affects, such as reward, feeding, anxiety, fear, sociability, and memory. However, it remains unclear how the LS, previously treated as… read more here.
Keywords: pieces lateral; multifaceted functions; putting together; together pieces ... See more keywords
Corticotropin-releasing factor system in the lateral septum: Implications in the pathophysiology of obesity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1020903
Abstract: Obesity is a pandemic associated with lifestyles changes. These include excess intake of obesogenic foods and decreased physical activity. Brain areas, like the lateral hypothalamus (LH), ventral tegmental area (VTA), and nucleus accumbens (NAcc) have… read more here.
Keywords: obesity; corticotropin releasing; releasing factor; lateral septum ... See more keywords
Characterizing defective lipid metabolism in the lateral septum of mice treated with olanzapine: implications for its side effects
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1419098
Abstract: Schizophrenia significantly impacts cognitive and behavioral functions and is primarily treated with second-generation antipsychotics (SGAs) such as olanzapine. Despite their efficacy, these drugs are linked to serious metabolic side effects which can diminish patient compliance,… read more here.
Keywords: mice; lipid metabolism; metabolism; side effects ... See more keywords
Stimulation of GABA Receptors in the Lateral Septum Rapidly Elicits Food Intake and Mediates Natural Feeding
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12070848
Abstract: The increasing prevalence of obesity and eating disorders makes identifying neural substrates controlling eating and regulating body weight a priority. Recent studies have highlighted the role of the lateral septum (LS) in eating control mechanisms.… read more here.
Keywords: gaba receptors; food intake; lateral septum;
Optogenetic Suppression of Lateral Septum Somatostatin Neurons Enhances Hippocampus Cholinergic Theta Oscillations and Local Synchrony
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci13010001
Abstract: The septal complex regulates both motivated and innate behaviors, chiefly by the action of its diverse population of long-range projection neurons. A small population of somatostatin-expressing GABAergic cells in the lateral septum projects deep into… read more here.
Keywords: septum somatostatin; somatostatin; theta oscillations; lateral septum ... See more keywords
Activation of Somatostatin-Expressing Neurons in the Lateral Septum Improves Stress-Induced Depressive-like Behaviors in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14102253
Abstract: Depression is a debilitating mood disorder with highly heterogeneous pathogenesis. The limbic system is well-linked to depression. As an important node in the limbic system, the lateral septum (LS) can modulate multiple affective and motivational… read more here.
Keywords: somatostatin expressing; depression; depressive like; lssst neurons ... See more keywords