Ndr/Lats kinases bind specific Mob-family coactivators through a conserved and modular interface.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b01096
Abstract: Ndr/Lats kinases bind Mob coactivator proteins to form complexes that are essential and deeply conserved components of "Hippo" signaling pathways, which control cell proliferation and morphogenesis in eukaryotes. All Ndr/Lats kinases have a characteristic N-terminal… read more here.
Keywords: ndr lats; specific mob; lats kinases; interface ... See more keywords
p190A RhoGAP induces CDH1 expression and cooperates with E-cadherin to activate LATS kinases and suppress tumor cell growth
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1385-2
Abstract: The ARHGAP35 gene encoding p190A RhoGAP (p190A) is significantly altered by both mutation and allelic deletion in human cancer, but the functional implications of such alterations are not known. Here, we demonstrate for the first… read more here.
Keywords: p190a rhogap; p190a; lats kinases; expression ... See more keywords