Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental biology"
DOI: 10.1016/j.ydbio.2021.01.012
Abstract: Proliferation and differentiation of vocal fold epithelial cells during embryonic development is poorly understood. We examined the role of Hippo signaling, a vital pathway known for regulating organ size, in murine laryngeal development. Conditional inactivation… read more here.
Keywords: role hippo; lats1 lats2; vocal fold; inactivation ... See more keywords
Lats1/2-Mediated Alteration of Hippo Signaling Pathway Regulates the Fate of Bone Marrow-Derived Mesenchymal Stem Cells
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DOI: 10.1155/2018/4387932
Abstract: Bone marrow-derived mesenchymal stem cells (BMSCs) can be used to enhance lung repair in acute respiratory distress syndrome (ARDS); however, the repairing effect is limited by poor homing and retention of BMSCs. The purpose of… read more here.
Keywords: lats1 lats2; signaling pathway; hippo signaling; bmscs ... See more keywords
Abstract B06: Development of selective LATS1/LATS2 inhibitors for the pharmacologic modulation of the Hippo signaling pathway
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DOI: 10.1158/1557-3125.hippo19-b06
Abstract: We performed a large-scale profiling of currently available kinase inhibitors (KI) to identify “off-targets” that could be repurposed/repositioned as the starting point for the rational development of novel and selective kinase inhibitors against underdrugged targets.… read more here.
Keywords: hippo; selective lats1; lats1 lats2; lats2 inhibitors ... See more keywords
Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113585
Abstract: Hippo signaling plays an essential role in the development of numerous tissues. Although it was previously shown that the transcriptional effectors of Hippo signaling Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) can… read more here.
Keywords: lats1 lats2; cell; testis; testis development ... See more keywords