Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload
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DOI: 10.1038/s41598-021-02846-3
Abstract: The Hippo pathway plays a wide variety of roles in response to stress in the heart. Lats2, a component of the Hippo pathway, is phosphorylated by Mst1/2 and, in turn, phosphorylates YAP, causing inactivation of… read more here.
Keywords: lats2; p53; lats2 mice; heart ... See more keywords
hsa_circ_0020093 suppresses ovarian cancer progression by modulating LRPPRC activity and miR-107/LATS2 signaling
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DOI: 10.1186/s13062-024-00520-y
Abstract: A substantive body of evidence has demonstrated the significant roles of circular RNA (circRNA) in cancer. However, the contribution of dysregulated circRNAs to ovarian cancer (OC) remains elusive. We aim to elucidate the critical roles… read more here.
Keywords: hsa circ; lats2; circ 0020093; mir 107 ... See more keywords
N6-methyladenosine modification of LATS2 promotes hepatoblastoma progression by inhibiting ferroptosis through the YAP1/ATF4/PSAT1 axis
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DOI: 10.7150/ijbs.92413
Abstract: Ferroptosis has attracted extensive interest from cancer researchers due to its substantial potential as a therapeutic target. The role of LATS2, a core component of the Hippo pathway cascade, in ferroptosis initiation in hepatoblastoma (HB)… read more here.
Keywords: lats2; ferroptosis; modification; atf4 psat1 ... See more keywords