Lacrimal Gland and Orbital Lesions in LatY136F Knock-in Mice, a Model for Human IgG4-Related Ophthalmic Disease
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DOI: 10.1080/02713683.2022.2103152
Abstract: Abstract Purpose LatY136F knock-in mice were recently proposed as an animal model for immunoglobulin G4 (IgG4)-related disease. In this study, we investigated whether LatY136F knock-in mice exhibit ophthalmic lesions, specifically in the lacrimal and Harderian… read more here.
Keywords: laty136f knock; igg1 positive; harderian glands; knock mice ... See more keywords
The pronounced lung lesions developing in LATY136F knock-in mice mimic human IgG4-related lung disease
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0247173
Abstract: Rationale Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a novel clinical disease entity characterized by an elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. Pathological changes are most frequently seen in… read more here.
Keywords: igg4; knock mice; laty136f knock; disease ... See more keywords