In vivo imaging of calcium and glutamate responses to intracortical microstimulation reveals distinct temporal responses of the neuropil and somatic compartments in layer II/III neurons.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.119767
Abstract: OBJECTIVE Intracortical microelectrode implants can generate a tissue response hallmarked by glial scarring and neuron cell death within 100-150 μm of the biomaterial device. Many have proposed that any performance decline in intracortical microstimulation (ICMS) due… read more here.
Keywords: stimulation; layer iii; calcium; intracortical microstimulation ... See more keywords
Unique Molecular Regulation of Higher-Order Prefrontal Cortical Circuits: Insights into the Neurobiology of Schizophrenia.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.7b00505
Abstract: Schizophrenia is associated with core deficits in cognitive abilities and impaired functioning of the newly evolved prefrontal association cortex (PFC). In particular, neuropathological studies of schizophrenia have found selective atrophy of the pyramidal cell microcircuits… read more here.
Keywords: molecular regulation; regulation higher; layer iii; unique molecular ... See more keywords
Increased glutamatergic synaptic transmission during development in layer II/III mouse motor cortex pyramidal neurons.
Sign Up to like & getrecommendations! Published in 2022 at "Cerebral cortex"
DOI: 10.1093/cercor/bhac368
Abstract: Postnatal maturation of the motor cortex is vital to developing a variety of functions, including the capacity for motor learning. The first postnatal weeks involve many neuronal and synaptic changes, which differ by region and… read more here.
Keywords: layer iii; development; motor; motor cortex ... See more keywords
Multiple Patterns of Axonal Collateralization of Single Layer III Neurons of the Rat Presubiculum
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2019.00045
Abstract: The presubiculum plays a key role in processing and integrating spatial and head-directional information. Layer III neurons of the presubiculum provide strong projections to the superficial layers of the medial entorhinal cortex (MEC) in the… read more here.
Keywords: iii neurons; rat presubiculum; layer; layer iii ... See more keywords
Taurine depletion during fetal and postnatal development blunts firing responses of neocortical layer II/III pyramidal neurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.806798
Abstract: Fetal and infant brains are rich in maternally derived taurine. We previously demonstrated that taurine action regulates the cation-chloride cotransporter activity and the differentiation and radial migration of pyramidal neuron progenitors in the developing neocortex… read more here.
Keywords: pyramidal neurons; taurine depletion; layer iii; iii pyramidal ... See more keywords