Effects of Acute Alcohol Exposure on Layer 5 Pyramidal Neurons of Juvenile Mice
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0571-4
Abstract: Early-onset drinking during childhood or preadolescence is a serious social problem. Yet, most of the basic neurobiological research on the acute effects of ethanol has been carried out on adult or early postnatal animals. We… read more here.
Keywords: alcohol exposure; exposure; pyramidal neurons; layer pyramidal ... See more keywords
Layer 2/3 Pyramidal Neurons Control the Gain of Cortical Output.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.08.038
Abstract: Initial anatomical and physiological studies suggested that sensory information relayed from the periphery by the thalamus is serially processed in primary sensory cortical areas. It is thought to propagate from layer 4 (L4) up to… read more here.
Keywords: layer; layer pyramidal; pyramidal neurons; output ... See more keywords
P135 Intermittent theta burst increases action potential threshold and spike firing in cortical layer 5 pyramidal neurons
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2016.10.257
Abstract: Introduction Repetitive transcranial magnetic stimulation has become a popular method of inducing neural plasticity in humans. In particular, complex patterned stimulation such as intermittent theta burst stimulation (iTBS) is routinely used to increase corticospinal excitably.… read more here.
Keywords: itbs; layer pyramidal; pyramidal neurons; spike firing ... See more keywords
Nicotine facilitates synaptic depression in layer V pyramidal neurons of the mouse insular cortex
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.02.046
Abstract: The insular cortex is known to play a pivotal role in addiction to nicotine. Long-term depression (LTD) in the central nervous system is a major form of synaptic plasticity which is involved in learning and… read more here.
Keywords: nicotine ltd; cortex; nicotine facilitates; insular cortex ... See more keywords
Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2018.02.016
Abstract: Voltage-dependent conductances not only drive action potentials but also help regulate neuronal resting potential. We found differential regulation of resting potential in the proximal axon of layer 5 pyramidal neurons compared to the soma. Axonal… read more here.
Keywords: resting potential; control; dependent conductances; layer pyramidal ... See more keywords
Excitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1101/2022.03.30.486368
Abstract: Dendrites of cortical pyramidal cells are densely populated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, a.k.a. Ih channels. Ih channels are targeted by multiple neuromodulatory pathways, and thus are one of the key ion-channel populations regulating… read more here.
Keywords: excitability; layer pyramidal; apical dendrite; pyramidal cells ... See more keywords
Clenbuterol reduces GABAergic transmission in prefrontal cortex layer 5/6 pyramidal neurons of juvenile rat via reducing action potentials firing frequency of GABAergic interneurons
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14248
Abstract: Beta‐adrenoceptors (β2‐ARs) have beneficial effects on prefrontal cortex (PFC) working memory, however, the cellular and molecular mechanisms are unclear yet. In this study, we probed the effect of β2‐AR‐selective agonist clenbuterol (Clen) on synaptic transmission… read more here.
Keywords: transmission; layer pyramidal; pyramidal neurons; gabaergic interneurons ... See more keywords
Burst control: Synaptic conditions for burst generation in cortical layer 5 pyramidal neurons
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1009558
Abstract: The output of neocortical layer 5 pyramidal cells (L5PCs) is expressed by a train of single spikes with intermittent bursts of multiple spikes at high frequencies. The bursts are the result of nonlinear dendritic properties,… read more here.
Keywords: apical tree; burst control; layer pyramidal; control synaptic ... See more keywords
Dopaminergic D1 receptor effects on commissural inputs targeting layer V pyramidal subtypes of the mouse medial prefrontal cortex
Sign Up to like & getrecommendations! Published in 2019 at "Physiological Reports"
DOI: 10.14814/phy2.14256
Abstract: In humans, prefrontal cortical areas are known to support goal‐directed behaviors, mediating a variety of functions that render behavior more flexible in the face of changing environmental demands. In mice, these functions are mediated by… read more here.
Keywords: layer pyramidal; medial prefrontal; activation; commissural inputs ... See more keywords
Drugs of Abuse Differentially Alter the Neuronal Excitability of Prefrontal Layer V Pyramidal Cell Subtypes
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.703655
Abstract: The medial prefrontal cortex (mPFC) plays an important role in regulating executive functions including reward seeking, task flexibility, and compulsivity. Studies in humans have demonstrated that drugs of abuse, including heroin, cocaine, methamphetamine, and alcohol,… read more here.
Keywords: pyramidal; layer pyramidal; physiology; excitability ... See more keywords
Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Computational Neuroscience"
DOI: 10.3389/fncom.2019.00066
Abstract: Pyramidal cells in layer V of the neocortex are one of the most widely studied neuron types in the mammalian brain. Due to their role as integrators of feedforward and cortical feedback inputs, they are… read more here.
Keywords: layer pyramidal; excitability; pyramidal cells; pathology ... See more keywords