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   Articles with "lc3" as a keyword



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VEGF‐A promotes angiogenesis after acute myocardial infarction through increasing ROS production and enhancing ER stress‐mediated autophagy

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.28395

Abstract: Proangiogenesis is generally regarded as an effective approach for treating ischemic heart disease. Vascular endothelial growth factor (VEGF)‐A is a strong and essential proangiogenic factor. Reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, and autophagy… read more here.

Keywords: lc3; production; vegf; grp78 bip ... See more keywords
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Engineered Cementitious Composites (ECC) with limestone calcined clay cement (LC3)

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recommendations! Published in 2020 at "Cement and Concrete Composites"

DOI: 10.1016/j.cemconcomp.2020.103766

Abstract: Abstract Recent research have recognized that coupled use of calcined clay, limestone and cement clinker in concrete is viable to reduce environmental footprints at manufacture and to enhance material durability. In this study, a novel… read more here.

Keywords: limestone calcined; lc3; calcined clay; cement ... See more keywords
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Investigating the potential of low-grade calcined clays to produce durable LC3 binders against chloride ions attack

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recommendations! Published in 2021 at "Construction and Building Materials"

DOI: 10.1016/j.conbuildmat.2021.124541

Abstract: Abstract Utilization of limestone calcined clay cements (LC3) as a recently developed ternary blends could be a promising economic approach to reduce the environmental impacts of Portland cement production. This study presents a comparative experimental… read more here.

Keywords: grade calcined; lc3; low grade; calcined clays ... See more keywords

Semisynthetic LC3 Probes for Autophagy Pathways Reveal a Noncanonical LC3 Interacting Region Motif Crucial for the Enzymatic Activity of Human ATG3

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recommendations! Published in 2023 at "ACS Central Science"

DOI: 10.1021/acscentsci.3c00009

Abstract: Macroautophagy is one of two major degradation systems in eukaryotic cells. Regulation and control of autophagy are often achieved through the presence of short peptide sequences called LC3 interacting regions (LIR) in autophagy-involved proteins. Using… read more here.

Keywords: lc3; atg3; semisynthetic lc3; region ... See more keywords
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SARS-CoV-2 promote autophagy to suppress type I interferon response

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recommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-021-00574-8

Abstract: Dear Editor, The outbreak of SARS-CoV-2 leads global epidemic with high morbidity and mortality. However, the pathophysiology of this deadly virus is complex and largely unknown. Autophagy is a highly conserved homeostatic process that allows… read more here.

Keywords: lc3; supplementary fig; sars cov; huh7 cells ... See more keywords
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A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/s41467-017-00303-2

Abstract: Upon induction of autophagy, the ubiquitin-like protein LC3 is conjugated to phosphatidylethanolamine (PE) on the inner and outer membrane of autophagosomes to allow cargo selection and autophagosome formation. LC3 undergoes two processing steps, the proteolytic… read more here.

Keywords: lc3; phosphorylation; protease; activity ... See more keywords
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Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging

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recommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2015368117

Abstract: Significance The elderly exhibit susceptibility to many infectious agents, including S. pneumoniae. A robust acute inflammatory response to S. pneumoniae is associated with severe disease. S. pneumoniae triggers canonical autophagy in nonprofessional phagocytes, but its… read more here.

Keywords: lc3; defense; pneumoniae; streptococcus pneumoniae ... See more keywords

SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production

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recommendations! Published in 2017 at "Autophagy"

DOI: 10.1080/15548627.2017.1291471

Abstract: ABSTRACT Macroautophagy/autophagy defects have been identified as critical factors underlying the pathogenesis of neurodegenerative diseases. The roles of the bioactive signaling lipid sphingosine-1-phosphate (S1P) and its catabolic enzyme SGPL1/SPL (sphingosine phosphate lyase 1) in autophagy… read more here.

Keywords: lc3; phosphate lyase; autophagy; sphingosine phosphate ... See more keywords
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Macrophages target Salmonella by Lc3-associated phagocytosis in a systemic infection model

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recommendations! Published in 2019 at "Autophagy"

DOI: 10.1080/15548627.2019.1569297

Abstract: ABSTRACT Innate immune defense against intracellular pathogens, like Salmonella, relies heavily on the autophagy machinery of the host. This response is studied intensively in epithelial cells, the target of Salmonella during gastrointestinal infections. However, little… read more here.

Keywords: lc3; lc3 associated; salmonella; target salmonella ... See more keywords
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The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress

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recommendations! Published in 2019 at "Autophagy"

DOI: 10.1080/15548627.2019.1662584

Abstract: ABSTRACT The trabecular meshwork (TM) is a key regulatory tissue of intraocular pressure (IOP) in the anterior chamber of eye. Dysfunction of the TM causes resistance to outflow of aqueous humor, which in turn leads… read more here.

Keywords: protein; lc3; mechanical stress; response cyclic ... See more keywords
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An optimized protocol for immuno-electron microscopy of endogenous LC3

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2056864

Abstract: ABSTRACT MAP1LC3/LC3 (microtubule associated protein 1 light chain 3) is widely used as marker of autophagic compartments at different stages of maturation. Electron microscopy (EM) combined with immunolabeling is the only technique that can reveal… read more here.

Keywords: electron microscopy; lc3; microscopy; endogenous lc3 ... See more keywords