Targeting PI3Kγ/AKT Pathway Remodels LC3‐Associated Phagocytosis Induced Immunosuppression After Radiofrequency Ablation
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DOI: 10.1002/advs.202102182
Abstract: Residual tumors after insufficient radiofrequency ablation (IRFA) shows accelerated progression and anti‐PD‐1 resistance. It is also reported that macrophages infiltrating into residual tumors leads to anti‐PD‐1 resistance. Elements of autophagy have been detected to conjugate… read more here.
Keywords: akt pathway; lc3 associated; residual tumors; pi3k akt ... See more keywords
Detection of LC3‐Associated Phagocytosis (LAP)
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DOI: 10.1002/cpcb.104
Abstract: Phagocytes, notably macrophages, are critical sentinels of their environment, patrolling for and eradicating unwanted components. The ability of cells to process extracellular cargo in an appropriate manner is important for both clearance of the cargo… read more here.
Keywords: associated phagocytosis; phagocytosis lap; lc3 associated; phagocytosis ... See more keywords
LAP it up, fuzz ball: a short history of LC3-associated phagocytosis.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2018.09.011
Abstract: LC3-associated phagocytosis (LAP) exists at the crossroads of the two evolutionary pathways of phagocytosis and autophagy. When a phagocyte engulfs an extracellular particle that engages receptor signaling, components of the autophagy machinery and Rubicon are… read more here.
Keywords: lc3 associated; phagocytosis; associated phagocytosis; lap fuzz ... See more keywords
Bioengineered Nanospores Selectively Blocking LC3-Associated Phagocytosis in Tumor-Associated Macrophages Potentiate Antitumor Immunity.
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DOI: 10.1021/acsnano.3c02657
Abstract: Although cytotoxic treatments hold tremendous potential in boosting antitumor immunity, efferocytosis of tumor-associated macrophages (TAMs) could negatively remove apoptotic tumor cells through LC3-associated phagocytosis (LAP), resulting in inefficient tumor antigen presentation and immunosuppressive tumor microenvironment.… read more here.
Keywords: lc3 associated; associated phagocytosis; associated macrophages; tumor ... See more keywords
LC3-associated phagocytosis initiated by integrin ITGAM-ITGB2/Mac-1 enhances immunity to Listeria monocytogenes
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2018.1475816
Abstract: ABSTRACT The macroautophagic/autophagic machinery cannot only target cell-endogenous components but also intracellular pathogenic bacteria such as Listeria monocytogenes. Listeria are targeted both by canonical autophagy and by a noncanonical form of autophagy referred to as… read more here.
Keywords: integrin itgam; lc3 associated; immunity; listeria ... See more keywords
Macrophages target Salmonella by Lc3-associated phagocytosis in a systemic infection model
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1569297
Abstract: ABSTRACT Innate immune defense against intracellular pathogens, like Salmonella, relies heavily on the autophagy machinery of the host. This response is studied intensively in epithelial cells, the target of Salmonella during gastrointestinal infections. However, little… read more here.
Keywords: lc3; lc3 associated; salmonella; target salmonella ... See more keywords
Targeting NR1H/liver X receptor with dendrogenin A differentiates tumor cells to activate a new secretory pathway releasing immunogenic anti-tumor vesicles enriched in LC3-II-associated exosomes
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2116175
Abstract: ABSTRACT Normal cells secrete small extracellular vesicles (sEV), containing exosomes and/or ectosomes, which play a beneficial role in monitoring tissue integrity and immune response, whereas cancer cells constitutively secrete sEV, which contribute to inhibit the… read more here.
Keywords: lc3 associated; dendrogenin; tumor cells; receptor ... See more keywords
Beyond autophagy: LC3-associated phagocytosis and endocytosis
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DOI: 10.1126/sciadv.abn1702
Abstract: Noncanonical functions of the autophagy machinery in pathways including LC3-associated phagocytosis and LC3-associated endocytosis have garnered increasing interest in both normal physiology and pathobiology. New discoveries over the past decade of noncanonical uses of the… read more here.
Keywords: beyond autophagy; lc3 associated; lc3; associated phagocytosis ... See more keywords
Control of infection by LC3-associated phagocytosis, CASM, and detection of raised vacuolar pH by the V-ATPase-ATG16L1 axis
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DOI: 10.1126/sciadv.abn3298
Abstract: The delivery of pathogens to lysosomes for degradation provides an important defense against infection. Degradation is enhanced when LC3 is conjugated to endosomes and phagosomes containing pathogens to facilitate fusion with lysosomes. In phagocytic cells,… read more here.
Keywords: lc3 associated; associated phagocytosis; atpase atg16l1; atpase ... See more keywords
LC3-associated endocytosis and the functions of Rubicon and ATG16L1
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DOI: 10.1126/sciadv.abo5600
Abstract: LC3-associated endocytosis (LANDO) is a noncanonical function of the autophagy machinery, in which LC3 (microtubule-associated protein light chain) is conjugated to rab5-positive endosomes, using a portion of the canonical autophagy pathway. LANDO was initially discovered… read more here.
Keywords: lc3 associated; rubicon atg16l1; endocytosis functions; functions rubicon ... See more keywords
LC3-Associated Phagocytosis (LAP): A Potentially Influential Mediator of Efferocytosis-Related Tumor Progression and Aggressiveness
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01298
Abstract: One aim of cancer therapies is to induce apoptosis of tumor cells. Efficient removal of the apoptotic cells requires coordinated efforts between the processes of efferocytosis and LC3-associated phagocytosis (LAP). However, this activity has also… read more here.
Keywords: tumor progression; lc3 associated; associated phagocytosis; efferocytosis ... See more keywords