Endomembrane damage sensing by V-ATPase recruits ATG16L1 for LC3 lipidation in situ.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2062889
Abstract: LC3 lipidation-mediated selective macroautophagy/autophagy helps eukaryotes to defend against endogenous dangers and foreign invaders. However, LC3 activation mechanisms of selective autophagy are still elusive. We previously determined that the V-ATPase-ATG16L1 axis is critical for LC3… read more here.
Keywords: lipidation; lc3 lipidation; sensing atpase; damage sensing ... See more keywords
Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abg4922
Abstract: Reconstitution experiments show how different cargo receptors engage the autophagy machinery in unique ways to lipidate LC3. Selective autophagy of damaged mitochondria, protein aggregates, and other cargoes is essential for health. Cargo initiates phagophore biogenesis,… read more here.
Keywords: selective autophagy; cargo receptors; lc3 lipidation; cargo ... See more keywords