Microtubule-Associated Protein 1 Light Chain 3 (LC3) Isoforms in RPE and Retina.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-75402-4_74
Abstract: Microtubule-associated protein 1 light chain 3 (MAP1LC3), a human homologue of yeast Atg8, is an essential component of autophagy. LC3 plays a critical role in hybrid degradation pathways in which some but not all components… read more here.
Keywords: associated protein; microtubule associated; lc3a lc3b; light chain ... See more keywords
Quantitative analysis of autophagy-related protein LC3B by quantum-dot-based molecular imaging.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2020.12.007
Abstract: Autophagy is a process that facilitates the maintenance of intracellular homeostasis by removing unnecessary or dysfunctional cellular components. It plays a role in inhibiting tumorigenesis in the early stage of the disease and might promote… read more here.
Keywords: dot based; quantum dot; lc3b; based molecular ... See more keywords
Abundances of autophagy-related protein LC3B in granulosa cells, cumulus cells, and oocytes during atresia of pig antral follicles.
Sign Up to like & getrecommendations! Published in 2019 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2019.106225
Abstract: In mammals, apoptosis has been accepted as the type of programmed cell death (PCD) that occurs in ovarian follicles undergoing atresia. Results of recent studies, however, indicate autophagy may be an alternative mechanism involved in… read more here.
Keywords: protein; granulosa cells; atretic follicles; autophagy related ... See more keywords
LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes
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DOI: 10.1016/j.cub.2021.05.052
Abstract: Macroautophagy (hereafter referred to as autophagy) is a conserved process that promotes cellular homeostasis through the degradation of cytosolic components, also known as cargo. During autophagy, cargo is sequestered into double-membrane vesicles called autophagosomes, which… read more here.
Keywords: directional transport; lc3b t50; transport; transport autophagosomes ... See more keywords
A cancer associated somatic mutation in LC3B attenuates its binding to E1-like ATG7 protein and subsequent lipidation
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2018.1525476
Abstract: ABSTRACT Macroautophagy/autophagy is a conserved catabolic process that maintains cellular homeostasis under basal growth and stress conditions. In cancer, autophagy can either prevent or promote tumor growth, at early or advanced stages, respectively. We screened… read more here.
Keywords: protein; atg7; lipidation; cancer ... See more keywords
The role of LC3B in autophagy as an RNA-binding protein
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2111083
Abstract: ABSTRACT The hallmark of cellular events observed upon macroautophagic/autophagic induction is the conjugation of LC3B, one of the mammalian Atg8 homologs, with phosphatidylethanolamine. This conversion from LC3B-I (an unconjugated form) to LC3B-II (a conjugated form)… read more here.
Keywords: binding protein; rna binding; lc3b autophagy; lc3b ... See more keywords
LC3B is not recruited along with the autophagy elongation complex (ATG5-12/16L1) at HCV replication site and is dispensable for viral replication
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DOI: 10.1371/journal.pone.0205189
Abstract: Hepatitis C virus (HCV) infection is known to induce autophagosome accumulation as observed by the typical punctate cytoplasmic distribution of LC3B-II in infected cells. Previously, we showed that viral RNA-dependent RNA polymerase (NS5B) interacts with… read more here.
Keywords: viral replication; elongation complex; site; replication ... See more keywords