HMGCS2 promotes autophagic degradation of the amyloid-β precursor protein through ketone body-mediated mechanisms.
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DOI: 10.1016/j.bbrc.2017.03.069
Abstract: HMGCS2 (mitochondrial 3-hydroxy-3-methylglutaryl-COA synthase 2) is a control enzyme in ketogenesis. The mitochondrial localization and interaction with APP (β-amyloid precursor protein) suggest that HMGCS2 may play a role in the pathophysiology of AD (Alzheimer's disease).… read more here.
Keywords: precursor protein; hmgcs2; lc3ii; amyloid precursor ... See more keywords