LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation.
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic acids research"
DOI: 10.1093/nar/gkz263
Abstract: The tumor suppressor protein 53BP1 plays key roles in response to DNA double-strand breaks (DSBs) by serving as a master scaffold at the damaged chromatin. Current evidence indicates that 53BP1 assembles a cohort of DNA… read more here.
Keywords: 53bp1 effector; lc8; lc8 dynll1; checkpoint activation ... See more keywords
Novel linear motif filtering protocol reveals the role of the LC8 dynein light chain in the Hippo pathway
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DOI: 10.1371/journal.pcbi.1005885
Abstract: Protein-protein interactions (PPIs) formed between short linear motifs and globular domains play important roles in many regulatory and signaling processes but are highly underrepresented in current protein-protein interaction databases. These types of interactions are usually… read more here.
Keywords: protein; lc8; filtering protocol; motif ... See more keywords
Systematic identification of recognition motifs for the hub protein LC8
Sign Up to like & getrecommendations! Published in 2019 at "Life Science Alliance"
DOI: 10.26508/lsa.201900366
Abstract: LC8 is a eukaryotic hub protein that interacts with multifarious partners; analysis of more than 100 binding/nonbinding sequences led to an algorithm that predicts LC8 partners with 78% accuracy. Hub proteins participate in cellular regulation… read more here.
Keywords: lc8; systematic identification; protein lc8; anchor ... See more keywords
Linker Length Drives Heterogeneity of Multivalent Complexes of Hub Protein LC8 and Transcription Factor ASCIZ
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13030404
Abstract: LC8, a ubiquitous and highly conserved hub protein, binds over 100 proteins involved in numerous cellular functions, including cell death, signaling, tumor suppression, and viral infection. LC8 binds intrinsically disordered proteins (IDPs), and although several… read more here.
Keywords: lc8; hub protein; linker length; heterogeneity multivalent ... See more keywords