Mechanistic Insights into the Activation of Lecithin–Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00540
Abstract: The mechanistic details behind the activation of lecithin-cholesterol acyltransferase (LCAT) by apolipoprotein A-I (apoA-I) and its mimetic peptides are still enigmatic. Resolving the fundamental principles behind the LCAT activation will facilitate the design of advanced… read more here.
Keywords: activation lecithin; lcat; lecithin cholesterol; cholesterol acyltransferase ... See more keywords
Abstract 4367648: Fish-Eye Disease: A Case Report
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DOI: 10.1161/circ.152.suppl_3.4367648
Abstract: Description of Case: A 26-year-old female was referred to cardiology with bilateral corneal opacifications of four years’ duration, with no change in her visual acuity. Her workup revealed a high-density lipoprotein cholesterol (HDL-C) level of… read more here.
Keywords: eye disease; cholesterol; fish eye; lcat ... See more keywords
Proteomics-driven discovery of LCAT as a novel biomarker for liver metastasis in colorectal cancer
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DOI: 10.1186/s12885-025-13882-x
Abstract: This study aimed to identify molecular markers that influence liver metastasis in colorectal cancer (CRC) and assess their clinical relevance. Proteomic analysis compared differential protein expression between CRC patients with liver metastasis (CRLM) and those… read more here.
Keywords: cancer; crc; expression; liver metastasis ... See more keywords
Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT
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DOI: 10.1194/jlr.ra119000512
Abstract: The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of… read more here.
Keywords: healthy volunteers; lcat; esterification; hydroxycholesterol ... See more keywords
Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol
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DOI: 10.7554/elife.41604
Abstract: Lecithin:cholesterol acyltransferase (LCAT) and LCAT-activating compounds are being investigated as treatments for coronary heart disease (CHD) and familial LCAT deficiency (FLD). Herein we report the crystal structure of human LCAT in complex with a potent… read more here.
Keywords: cholesterol; cholesterol acyltransferase; compound; lecithin cholesterol ... See more keywords