Mechanistic Insights into the Activation of Lecithin–Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids
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DOI: 10.1021/acs.molpharmaceut.2c00540
Abstract: The mechanistic details behind the activation of lecithin-cholesterol acyltransferase (LCAT) by apolipoprotein A-I (apoA-I) and its mimetic peptides are still enigmatic. Resolving the fundamental principles behind the LCAT activation will facilitate the design of advanced… read more here.
Keywords: activation lecithin; lcat; lecithin cholesterol; cholesterol acyltransferase ... See more keywords
Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT
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DOI: 10.1194/jlr.ra119000512
Abstract: The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of… read more here.
Keywords: healthy volunteers; lcat; esterification; hydroxycholesterol ... See more keywords
Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol
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DOI: 10.7554/elife.41604
Abstract: Lecithin:cholesterol acyltransferase (LCAT) and LCAT-activating compounds are being investigated as treatments for coronary heart disease (CHD) and familial LCAT deficiency (FLD). Herein we report the crystal structure of human LCAT in complex with a potent… read more here.
Keywords: cholesterol; cholesterol acyltransferase; compound; lecithin cholesterol ... See more keywords