CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH‐associated neurodegeneration and mass lesions
Sign Up to like & getrecommendations! Published in 2018 at "Cancer"
DOI: 10.1002/cncr.31348
Abstract: Central nervous system Langerhans cell histiocytosis (CNS‐LCH) brain involvement may include mass lesions and/or a neurodegenerative disease (LCH‐ND) of unknown etiology. The goal of this study was to define the mechanisms of pathogenesis that drive… read more here.
Keywords: langerhans cell; cell histiocytosis; mass lesions; lch ... See more keywords
High levels of plasma interleukin-17A are associated with severe neurological sequelae in Langerhans cell histiocytosis.
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.154877
Abstract: OBJECTIVE Langerhans cell histiocytosis (LCH) is a granulomatous inflammatory myeloid neoplasia associated with a cytokine storm in both serum and lesions. Increased levels of plasma interleukin-17A (IL-17A) in LCH patients have been reported, but this… read more here.
Keywords: langerhans cell; levels plasma; 17a lch; cell histiocytosis ... See more keywords
Anti TNF-α therapy in patients with relapsed and refractory Langerhans cell histiocytosis: a phase II study
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2018.1539149
Abstract: Abstract Tumor necrosis factor alpha (TNF-α) is produced in Langerhans cell histiocytosis (LCH) lesions and is elevated in plasma of patients with active LCH. It has been postulated that TNF-α may play a role in… read more here.
Keywords: langerhans cell; study; cell histiocytosis; anti tnf ... See more keywords
Efficacy and safety of vemurafenib in Langerhans cell histiocytosis (LCH): A systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2022.2072986
Abstract: Abstract Almost half of the patients with Langerhans cell histiocytosis (LCH) are refractory to primary induction chemotherapy or undergo reactivation. The ideal treatment modality for refractory/relapsed LCH is yet not evidenced. This review aimed to… read more here.
Keywords: vemurafenib; langerhans cell; histiocytosis lch; lch ... See more keywords
Adult Langerhans’ cell histiocytosis with multisystem involvement
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DOI: 10.1097/md.0000000000013366
Abstract: Rationale: Langerhans’ cell histiocytosis (LCH), also called histiocytosis X, is an uncommon disorder manifesting in a variety of ways. Although LCH can involve various organs including bone, skin, and lymph nodes, multisystem involvement of LCH… read more here.
Keywords: langerhans cell; histiocytosis; cell histiocytosis; bone ... See more keywords
High prevalence of peripheral lymphopenia in Langerhans cell histiocytosis
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.16923
Abstract: In the inflammatory myeloid neoplasia called Langerhans cell histiocytosis (LCH), leukocytes accumulate in tissues causing granulomatous lesions. The disease ranges from mild (singlesystem, SS) to severe (multisystem, MS) manifestations with potential involvement of risk organs… read more here.
Keywords: lymphopenia; diagnosis; treatment; prevalence ... See more keywords
Targeting of SIRPα as a potential therapy for Langerhans cell histiocytosis
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DOI: 10.1111/cas.15758
Abstract: Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder characterized by inflammatory lesions arising from the anomalous accumulation of pathogenic CD1a+CD207+ dendritic cells (DCs). SIRPα is a transmembrane protein highly expressed in myeloid cells such… read more here.
Keywords: cd11c; langerhans cell; lch; cell histiocytosis ... See more keywords
Acral angioleiomyoma with tumoral calcinosis: a complication of the insertional Achilles tendinopathy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cutaneous Pathology"
DOI: 10.1111/cup.12956
Abstract: (Figure 2). Scattered neutrophils, eosinophils and extravasated red blood cells were also present in the background. On immunohistochemistry, the small histiocytes strongly stained with CD1a and langerin while the MGCs were variably positive for CD1a… read more here.
Keywords: medicine; pennsylvania; pathology; philadelphia ... See more keywords
Adult Langerhans cell histiocytosis with recurrent vulvar ulcers
Sign Up to like & getrecommendations! Published in 2020 at "Dermatologic Therapy"
DOI: 10.1111/dth.13387
Abstract: Dear Editor, A 19-year-old female patient was referred to dermatology outpatient clinic with recurrent, erythematous papules and ulcers on her breast and sternum present for 8 months. She subsequently developed painless ulcers on the mons… read more here.
Keywords: langerhans cell; skin; cell histiocytosis; lch ... See more keywords
Case report of Langerhans cell histiocytosis in a fetus detected by magnetic resonance imaging
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.14559
Abstract: Langerhans cell histiocytosis (LCH) is a rare disease, and the diagnosis of LCH is mainly based on clinical manifestation, imaging and pathological examinations. But during pregnancy, imaging examinations especially play an important role in the… read more here.
Keywords: langerhans cell; fetus; resonance imaging; magnetic resonance ... See more keywords
Not ‘just cradle cap’
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Paediatrics and Child Health"
DOI: 10.1111/jpc.2_15402
Abstract: The diagnosis is multi-system Langerhans cell histiocytosis (LCH). Water deprivation was consistent with central diabetes insipidus (DI) – paired serum osmolality of 305 mOsm/kg and urine osmolality of 113 mOsm/kg. The diagnosis of LCH was… read more here.
Keywords: bone; involvement; cradle cap; histopathology ... See more keywords