CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH‐associated neurodegeneration and mass lesions
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DOI: 10.1002/cncr.31348
Abstract: Central nervous system Langerhans cell histiocytosis (CNS‐LCH) brain involvement may include mass lesions and/or a neurodegenerative disease (LCH‐ND) of unknown etiology. The goal of this study was to define the mechanisms of pathogenesis that drive… read more here.
Keywords: langerhans cell; cell histiocytosis; mass lesions; lch ... See more keywords
High levels of plasma interleukin-17A are associated with severe neurological sequelae in Langerhans cell histiocytosis.
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DOI: 10.1016/j.cyto.2019.154877
Abstract: OBJECTIVE Langerhans cell histiocytosis (LCH) is a granulomatous inflammatory myeloid neoplasia associated with a cytokine storm in both serum and lesions. Increased levels of plasma interleukin-17A (IL-17A) in LCH patients have been reported, but this… read more here.
Keywords: langerhans cell; levels plasma; 17a lch; cell histiocytosis ... See more keywords
Isolated eyelid neonatal Langerhans cell histiocytosis
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DOI: 10.1080/01676830.2023.2300802
Abstract: ABSTRACT Langerhans cell histiocytosis (LCH) is a condition characterized by clonal proliferation of the phagocytic cells derived from the bone marrow. In this article, we present an exceedingly rare case of congenital/neonatal LCH in a… read more here.
Keywords: neonatal lch; isolated eyelid; lch; cell histiocytosis ... See more keywords
Anti TNF-α therapy in patients with relapsed and refractory Langerhans cell histiocytosis: a phase II study
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DOI: 10.1080/08880018.2018.1539149
Abstract: Abstract Tumor necrosis factor alpha (TNF-α) is produced in Langerhans cell histiocytosis (LCH) lesions and is elevated in plasma of patients with active LCH. It has been postulated that TNF-α may play a role in… read more here.
Keywords: langerhans cell; study; cell histiocytosis; anti tnf ... See more keywords
Efficacy and safety of vemurafenib in Langerhans cell histiocytosis (LCH): A systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2022.2072986
Abstract: Abstract Almost half of the patients with Langerhans cell histiocytosis (LCH) are refractory to primary induction chemotherapy or undergo reactivation. The ideal treatment modality for refractory/relapsed LCH is yet not evidenced. This review aimed to… read more here.
Keywords: vemurafenib; langerhans cell; histiocytosis lch; lch ... See more keywords
Advances in our understanding of genetic markers and targeted therapies for pediatric LCH
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DOI: 10.1080/17474086.2024.2353772
Abstract: ABSTRACT Introduction Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm, encompassing a diverse clinical spectrum ranging from localized bone or skin lesions to a multisystemic life-threatening condition. Over the past decade, there has been… read more here.
Keywords: targeted therapies; genetic markers; lch; pediatric lch ... See more keywords
Adult Langerhans’ cell histiocytosis with multisystem involvement
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DOI: 10.1097/md.0000000000013366
Abstract: Rationale: Langerhans’ cell histiocytosis (LCH), also called histiocytosis X, is an uncommon disorder manifesting in a variety of ways. Although LCH can involve various organs including bone, skin, and lymph nodes, multisystem involvement of LCH… read more here.
Keywords: langerhans cell; histiocytosis; cell histiocytosis; bone ... See more keywords
Delayed diagnosis of pituitary LCH with BRAFV600E mutation: A case report and literature review
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DOI: 10.1097/md.0000000000045274
Abstract: Rationale: This case report highlights the diagnostic challenges and clinical complexities of adult-onset pituitary Langerhans Cell Histiocytosis (LCH), a rare entity with a prolonged and indolent progression. This underscores the critical need for heightened clinical… read more here.
Keywords: lch; brafv600e mutation; case report;
A challenging diagnosis of Langerhans’ cell histiocytosis with hypothalamic-pituitary and mandibular involvement: case report and literature review
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DOI: 10.1097/ms9.0000000000002160
Abstract: Background: Langerhans cell histiocytosis (LCH) is a rare bone marrow derived neoplasm that mainly affects children. It is a multiorgan disorder and hypothalamic-pituitary involvement is uncommon. LCH reveals a wide spectrum of indications; thus, the… read more here.
Keywords: diagnosis; hypothalamic pituitary; lch; case ... See more keywords
High prevalence of peripheral lymphopenia in Langerhans cell histiocytosis
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DOI: 10.1111/bjh.16923
Abstract: In the inflammatory myeloid neoplasia called Langerhans cell histiocytosis (LCH), leukocytes accumulate in tissues causing granulomatous lesions. The disease ranges from mild (singlesystem, SS) to severe (multisystem, MS) manifestations with potential involvement of risk organs… read more here.
Keywords: lymphopenia; diagnosis; treatment; prevalence ... See more keywords
Targeting of SIRPα as a potential therapy for Langerhans cell histiocytosis
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DOI: 10.1111/cas.15758
Abstract: Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder characterized by inflammatory lesions arising from the anomalous accumulation of pathogenic CD1a+CD207+ dendritic cells (DCs). SIRPα is a transmembrane protein highly expressed in myeloid cells such… read more here.
Keywords: cd11c; langerhans cell; lch; cell histiocytosis ... See more keywords