High levels of plasma interleukin-17A are associated with severe neurological sequelae in Langerhans cell histiocytosis.
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.154877
Abstract: OBJECTIVE Langerhans cell histiocytosis (LCH) is a granulomatous inflammatory myeloid neoplasia associated with a cytokine storm in both serum and lesions. Increased levels of plasma interleukin-17A (IL-17A) in LCH patients have been reported, but this… read more here.
Keywords: langerhans cell; levels plasma; 17a lch; cell histiocytosis ... See more keywords
High prevalence of peripheral lymphopenia in Langerhans cell histiocytosis
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DOI: 10.1111/bjh.16923
Abstract: In the inflammatory myeloid neoplasia called Langerhans cell histiocytosis (LCH), leukocytes accumulate in tissues causing granulomatous lesions. The disease ranges from mild (singlesystem, SS) to severe (multisystem, MS) manifestations with potential involvement of risk organs… read more here.
Keywords: lymphopenia; diagnosis; treatment; prevalence ... See more keywords
Neutralizing Anti-IL-17A Antibody Demonstrates Preclinical Activity Enhanced by Vinblastine in Langerhans Cell Histiocytosis
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DOI: 10.3389/fonc.2021.780191
Abstract: Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasm characterised by the accumulation into granulomas of apoptosis-resistant pathological dendritic cells (LCH-DCs). LCH outcome ranges from self-resolving to fatal. Having previously shown that, (i) monocyte-derived DCs… read more here.
Keywords: lch patients; dcs lch; neutralizing anti; expression ... See more keywords