Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1.
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia research"
DOI: 10.1016/j.leukres.2019.01.006
Abstract: Acute myeloid leukemia (AML) is a heterogeneous group of fast growing cancers of myeloid progenitor cells, for which effective treatments are still lacking. Identification of signaling inhibitors that block their proliferation could reveal the proliferative… read more here.
Keywords: cell; lck; myeloid leukemia; proliferation ... See more keywords
Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function
Sign Up to like & getrecommendations! Published in 2020 at "Nature Immunology"
DOI: 10.1038/s41590-020-0732-3
Abstract: Initiation of T cell antigen receptor (TCR) signaling involves phosphorylation of CD3 cytoplasmic tails by the tyrosine kinase Lck. How Lck is recruited to the TCR to initiate signaling is not well known. We report… read more here.
Keywords: cd3; lck; function; binding lck ... See more keywords
Sorting Nexin 27-dependent regulation of Lck and CD4 tunes the initial stages of T-cell activation.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiae086
Abstract: Sorting nexin (SNX) 27 is a unique member of the SNX family of proteins that mediates the endosome-to-plasma membrane trafficking of cargos bearing a PSD95/Dlg1/ZO-1 (PDZ)-binding motif. In brain, SNX27 regulates synaptic plasticity, and its… read more here.
Keywords: snx27 expression; lck; sorting nexin; activation ... See more keywords
PTPN22-CD45 dual phosphatase retrograde feedback enhances TCR signaling and autoimmunity
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adw2568
Abstract: Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) is encoded by a gene strongly associated with lupus and other autoimmune diseases. PTPN22 regulates T cell receptor (TCR) signaling through dephosphorylation of the kinases lymphocyte-specific protein tyrosine… read more here.
Keywords: ptpn22 ser449; tcr signaling; phosphorylation; lck ... See more keywords
Low expressed SRSF1 promotes lck exon 8 skipping to attenuate TCR signaling and treg induction in immune thrombocytopenia
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DOI: 10.1182/blood-2025-4779
Abstract: Introduction: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by platelet destruction and impaired production. A key feature involves dysfunctional immune regulation, particularly impaired regulatory T cell (Treg) frequency and function. While Treg deficiencies in… read more here.
Keywords: treg induction; srsf1; tcr signaling; lck ... See more keywords
A comprehensive analysis of the expression and regulation network of lymphocyte-specific protein tyrosine kinase in breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Translational Cancer Research"
DOI: 10.21037/tcr-21-328
Abstract: Background Lymphocyte-specific protein tyrosine kinase (LCK), an encoded Src family protein tyrosine kinase, performs a pivotal molecular signaling role in the selection and maturation processes during T-cell development. Although aberrant LCK expression is known to… read more here.
Keywords: cancer; analysis; expression; lck ... See more keywords
Blockade of Tyrosine Kinase, LCK Leads to Reduction in Airway Inflammation through Regulation of Pulmonary Th2/Treg Balance and Oxidative Stress in Cockroach Extract-Induced Mouse Model of Allergic Asthma
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12090793
Abstract: Asthma is one of the most common inflammatory diseases affecting the airways. Approximately 300 million individuals suffer from asthma around the world. Allergic immune responses in the asthmatic airways are predominantly driven by Th2 cells… read more here.
Keywords: inflammation; treg; oxidative stress; airway inflammation ... See more keywords