Racial variations in lacosamide serum concentrations in adult patients with epilepsy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2020.116742
Abstract: Lacosamide (LCM) is a third-generation anti-epileptic drug (AED) for partial-onset epilepsy with minimal hepatic metabolism and drug-drug interactions. The impact of individual patient variables such as race on drug metabolism have been under-reported in AEDs… read more here.
Keywords: daily dose; lcm levels; drug; racial variations ... See more keywords
The effect of wellbore circulation on building an LCM bridge at the fracture aperture
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Petroleum Science and Engineering"
DOI: 10.1016/j.petrol.2018.02.034
Abstract: Abstract Different laboratory experimental setups with slotted disks, simulating fractures’ apertures, have been used extensively to formulate effective loss circulation materials (LCM) recipes. The amount of fluid loss and sealing pressure have been used as… read more here.
Keywords: effect; wellbore circulation; lcm; lcm recipes ... See more keywords
An Integrated Local Classification Model of Predicting Drug-Drug Interactions via Dempster-Shafer Theory of Evidence
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30189-z
Abstract: Drug-drug interactions (DDIs) may trigger adverse drug reactions, which endanger the patients. DDI identification before making clinical medications is critical but bears a high cost in clinics. Computational approaches, including global model-based and local model… read more here.
Keywords: model based; drug interactions; drug; model ... See more keywords
Coupled CFD-DEM simulation of granular LCM bridging in a fracture
Sign Up to like & getrecommendations! Published in 2019 at "Particulate Science and Technology"
DOI: 10.1080/02726351.2018.1547341
Abstract: Abstract Developed fractures are important storage space and permeable channel in hydrocarbon reservoirs. However, they will lead to drill-in fluid loss and induce severe formation damage. Fracture plugging with granular lost circulation material (LCM) is… read more here.
Keywords: fracture; lcm bridging; bridging fracture; particle ... See more keywords
Beneficial Combination of Lacosamide with Retigabine in Experimental Animals: An Isobolographic Analysis
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacology"
DOI: 10.1159/000480019
Abstract: Background/Aim: To isobolographically determine the types of interactions that occur between retigabine and lacosamide (LCM; two third-generation antiepileptic drugs) with respect to their anticonvulsant activity and acute adverse effects (sedation) in the maximal electroshock-induced seizures… read more here.
Keywords: isobolographic analysis; combination; chimney test; analysis ... See more keywords
Measuring Abstract Mind-Sets Through Syntax: Automating the Linguistic Category Model
Sign Up to like & getrecommendations! Published in 2019 at "Social Psychological and Personality Science"
DOI: 10.1177/1948550619848004
Abstract: Abstraction in language has critical implications for memory, judgment, and learning and can provide an important window into a person’s cognitive abstraction level. The linguistic category model (LCM) provides one well-validated, human-coded approach to quantifying… read more here.
Keywords: category model; abstraction; lcm; syntax ... See more keywords
Evaluation of Cardiovascular Concerns of Intravenous Lacosamide Therapy in Epilepsy Patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.891368
Abstract: Objective Voltage-gated sodium channels (VGSCs) play an important role in neuronal excitability and epilepsies. In addition to the brain, VGSCs are also abundant enriched in cardiac tissues and are responsible for normal cardiac rhythm. Theoretically,… read more here.
Keywords: epilepsy patients; therapy; intravenous lcm; pressure ... See more keywords
Plasma lacosamide monitoring in children with epilepsy: Focus on reference therapeutic range and influencing factors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.949783
Abstract: Background Lacosamide (LCM) is a newer anti-seizure medication (ASM) that was approved in China in 2018, but its real-world clinical data and plasma concentrations in Chinese children with epilepsy are very limited. Of note, the… read more here.
Keywords: children epilepsy; reference; dose ratio; range ... See more keywords
Interactions among Lacosamide and Second-Generation Antiepileptic Drugs in the Tonic-Clonic Seizure Model in Mice
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22115537
Abstract: Combination therapy with two or three antiseizure medications (ASMs) is sometimes a preferred method of treatment in epilepsy patients. (1) Background: To detect the most beneficial combination among three ASMs, a screen test evaluating in… read more here.
Keywords: seizure; among lacosamide; lcm; interactions among ... See more keywords
A Numerical Thermo-Chemo-Flow Analysis of Thermoset Resin Impregnation in LCM Processes
Sign Up to like & getrecommendations! Published in 2023 at "Polymers"
DOI: 10.3390/polym15061572
Abstract: This paper presents a numerical framework for modelling and simulating convection–diffusion–reaction flows in liquid composite moulding (LCM). The model is developed in ANSYS Fluent with customised user-defined-functions (UDFs), user-defined-scalar (UDS), and user-defined memory (UDM) codes… read more here.
Keywords: resin impregnation; flow; thermoset resin; lcm ... See more keywords