CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence in resected G1 and G2 pancreatic neuroendocrine tumors
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2232
Abstract: Although the postoperative recurrence rate for pancreatic neuroendocrine tumors (PNETs) is reported to be 13.5%‐30%, the paucity of valuable biomarkers to predict recurrence poses a problem for the early detection of relapse. Hence, this study… read more here.
Keywords: lcn2; pancreatic neuroendocrine; recurrence; clec3a mmp7 ... See more keywords
Associations between circulating bone-derived hormones lipocalin 2, osteocalcin, and glucose metabolism in acromegaly
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-020-01221-9
Abstract: Purpose The aim was to examine changes in the bone-derived hormone lipocalin 2 (LCN2) levels in patients with active acromegaly and to investigate the potential roles of LCN2 and osteocalcin in glucose metabolism. Methods We… read more here.
Keywords: lcn2; glucose metabolism; osteocalcin glucose; bone derived ... See more keywords
Paradoxical role of lipocalin-2 in metabolic disorders and neurological complications.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.113626
Abstract: Lipocalin-2 (LCN2), also known as 24p3 and neutrophil gelatinase-associated lipocalin (NGAL), is a 25-kDa secreted protein implicated in various metabolic and inflammatory diseases.Early studies suggest the protective function of LCN2 in which it acts as… read more here.
Keywords: lcn2; neurological complications; lipocalin; metabolic disorders ... See more keywords
Liver parenchymal cells lacking Lipocalin 2 (LCN2) are prone to endoplasmic reticulum stress and unfolded protein response.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.01.001
Abstract: Unfolded protein response (UPR) is an adaptive mechanism allowing the endoplasmic reticulum (ER) to react to an accumulation of unfolded proteins in its lumen, also known as ER stress. The UPR is interconnected with inflammation… read more here.
Keywords: protein; lcn2; unfolded protein; protein response ... See more keywords
Corticoids synergize with IL-1 in the induction of LCN2.
Sign Up to like & getrecommendations! Published in 2017 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2017.01.017
Abstract: OBJECTIVE Lipocalin-2 (LCN2) is an adipokine that was first identified in neutrophil granules. In the last years it was recognized as a factor that could impair chondrocyte phenotype, cartilage homeostasis as well as growth plate… read more here.
Keywords: lcn2; expression lcn2; induction lcn2; corticoids synergize ... See more keywords
Lipocalin2 promotes cell proliferation and migration in ovarian cancer through activation of the ERK/GSK3β/β-catenin signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118492
Abstract: Lipocalin2 (Lcn2) has been shown to be a vital regulator of tumorigenesis in a variety of different cancers. However, its expression patterns and possible roles in ovarian cancer remain obscure. The aim of this study… read more here.
Keywords: lcn2; cell proliferation; migration; ovarian cancer ... See more keywords
Astrocyte-derived lipocalin-2 is involved in mitochondrion-related neuronal apoptosis induced by methamphetamine.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00559
Abstract: Methamphetamine (METH) is a widely abused and highly addictive psychoactive stimulant that can induce neuronal apoptosis. Lipocalin-2 (LCN2) is a member of the lipocalin family, and its upregulation is involved in cell death in the… read more here.
Keywords: related neuronal; lcn2; apoptosis; mitochondrion related ... See more keywords
Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22361-3
Abstract: Lipocalin 2 (LCN2) was recently identified as an endogenous ligand of the type 4 melanocortin receptor (MC4R), a critical regulator of appetite. However, it remains unknown if this molecule influences appetite during cancer cachexia, a… read more here.
Keywords: lcn2; appetite suppression; pancreatic cancer; cancer cachexia ... See more keywords
Lipocalin-2 deficiency may predispose to the progression of spontaneous age-related adiposity in mice
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-71249-7
Abstract: Lipocalin-2 (Lcn2) is an innate immune protein elevated by several orders of magnitude in various inflammatory conditions including aging and obesity. Recent studies have shown that Lcn2 is secreted by adipocytes in response to inflammation… read more here.
Keywords: lcn2; age; mice; lipocalin deficiency ... See more keywords
Subtilase cytotoxin induces a novel form of Lipocalin 2, which promotes Shiga-toxigenic Escherichia coli survival
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-76027-z
Abstract: Shiga-toxigenic Escherichia coli (STEC) infection causes severe bloody diarrhea, renal failure, and hemolytic uremic syndrome. Recent studies showed global increases in Locus for Enterocyte Effacement (LEE)-negative STEC infection. Some LEE-negative STEC produce Subtilase cytotoxin (SubAB),… read more here.
Keywords: shiga toxigenic; lcn2; escherichia coli; subtilase cytotoxin ... See more keywords
Reduced secretion of LCN2 (lipocalin 2) from reactive astrocytes through autophagic and proteasomal regulation alleviates inflammatory stress and neuronal damage.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2180202
Abstract: LCN2/neutrophil gelatinase-associated lipocalin/24p3 (lipocalin 2) is a secretory protein that acts as a mammalian bacteriostatic molecule. Under neuroinflammatory stress conditions, LCN2 is produced and secreted by activated microglia and reactive astrocytes, resulting in neuronal apoptosis.… read more here.
Keywords: reactive astrocytes; reduced secretion; lcn2; stress neuronal ... See more keywords