A metabolomics approach to profiling the cardioprotective effect of LCZ696, an angiotensin receptor-neprilysin inhibitor, on ischemia induced heart failure
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra01404j
Abstract: Heart failure is one of the most common chronic diseases in the world, particularly among the elderly, yet, no clinically approved metabolite biomarkers have been identified so far. To address this issue, we conducted a… read more here.
Keywords: heart; metabolism; lcz696; heart failure ... See more keywords
LCZ696 Ameliorates Oxidative Stress and Pressure Overload-Induced Pathological Cardiac Remodeling by Regulating the Sirt3/MnSOD Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/9815039
Abstract: Aims We aimed to investigate whether LCZ696 protects against pathological cardiac hypertrophy by regulating the Sirt3/MnSOD pathway. Methods In vivo, we established a transverse aortic constriction animal model to establish pressure overload-induced heart failure. Subsequently,… read more here.
Keywords: pressure overload; regulating sirt3; lcz696; sirt3 mnsod ... See more keywords
LCZ696 Ameliorates Isoproterenol-Induced Acute Heart Failure in Rats by Activating the Nrf2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Applied Bionics and Biomechanics"
DOI: 10.1155/2022/6077429
Abstract: Objective LCZ696 (sacubitril/valsartan) is an angiotensin II (Ang II) type 1 receptor-neprilysin inhibitor, with effects of immunosuppression, anti-inflammation, antiapoptosis, and antioxidation. The present study was aimed at determining whether LCZ696 has a protective effect against… read more here.
Keywords: isoproterenol induced; lcz696; signaling pathway; nrf2 signaling ... See more keywords
AHU377+Valsartan (LCZ696) Modulates Renin–Angiotensin System (RAS) in the Cardiac of Female Spontaneously Hypertensive Rats Compared With Valsartan
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Pharmacology and Therapeutics"
DOI: 10.1177/1074248419838503
Abstract: Background: Hypertension is a major cause of death and morbidity worldwide and is increasing in prevalence. The Renin–angiotensin system (RAS) is the most common mechanism involved in the pathophysiology of hypertension. Understanding the mechanism of… read more here.
Keywords: lcz696; expression; compared valsartan; angiotensin ... See more keywords
LCZ696 protects against doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via AKT/SIRT3/SOD2 signaling pathway activation.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.2139/ssrn.4153607
Abstract: Doxorubicin (DOX) is an effective and widely used anticancer drug but has limited clinical applicability because of its cardiotoxicity. Ferroptosis plays a key role in DOX-induced cardiac damage and cardiomyocyte cell death. The inhibition of… read more here.
Keywords: induced cardiotoxicity; lcz696; cardiotoxicity; inhibiting ferroptosis ... See more keywords