Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T‐cell acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Communications"
DOI: 10.1002/cac2.12080
Abstract: T‐cell acute lymphoblastic leukemia (T‐ALL) is an uncommon and aggressive subtype of acute lymphoblastic leukemia (ALL). In the serum of T‐ALL patients, the activity of lactate dehydrogenase A (LDHA) is increased. We proposed that targeting… read more here.
Keywords: cell acute; lymphoblastic leukemia; acute lymphoblastic; lactate dehydrogenase ... See more keywords
miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.04.034
Abstract: Lactate dehydrogenase A (LDHA), a key enzyme regulating aerobic glycolysis, is overexpressed in many human cancers, and correlates with poor clinical outcomes. Aerobic glycolysis is a hallmark of cancer, and drugs targeting its regulators, including… read more here.
Keywords: inhibition ldha; expression; cancer; mir 30a ... See more keywords
ANXA2P2/miR-9/LDHA axis regulates Warburg effect and affects glioblastoma proliferation and apoptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109718
Abstract: BACKGROUND Aerobic glycolysis is a unique tumor cell phenotype considered as one of the hallmarks of cancer. Aerobic glycolysis can accelerate tumor development by increasing glucose uptake and lactate production. In the present study, lactate… read more here.
Keywords: glycolysis; glioma; anxa2p2; mir ... See more keywords
Escherichia coli genome-scale metabolic gene knockout of lactate dehydrogenase (ldhA), increases succinate production from glycerol
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2017.1395768
Abstract: Genome-scale metabolic model (GEM) of Escherichia coli has been published with applications in predicting metabolic engineering capabilities on different carbon sources and directing biological discovery. The use of glycerol as an alternative carbon source is… read more here.
Keywords: escherichia coli; succinate production; ldha; glycerol ... See more keywords
Inhibition of LDHA to Induce EEF2 Release Enhances Thrombocytopoiesis.
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DOI: 10.1182/blood.2022015620
Abstract: Translation is essential for megakaryocyte (MK) maturation and platelet production. However, how the translational pathways are regulated in this process remains unknown. In this study, we found that megakaryocyte/platelet-specific lactate dehydrogenase A (LdhA)-knockout mice showed… read more here.
Keywords: inhibition ldha; ldha induce; maturation; platelet ... See more keywords
Starvation induced autophagy promotes the progression of bladder cancer by LDHA mediated metabolic reprogramming
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-02303-1
Abstract: Background Aberrant autophagy and preternatural elevated glycolysis are prevalent in bladder cancer (BLCA) and are both related to malignant progression. However, the regulatory relationship between autophagy and glycolytic metabolism remains largely unknown. We imitated starvation… read more here.
Keywords: starvation induced; cancer; progression; induced autophagy ... See more keywords
4-OI Protects MIN6 Cells from Oxidative Stress Injury by Reducing LDHA-Mediated ROS Generation
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12091236
Abstract: Pancreatic beta cells are highly susceptible to oxidative stress, which plays a crucial role in diabetes outcomes. Progress has been slow to identify molecules that could be utilized to enhance cell survival and function under… read more here.
Keywords: cells oxidative; stress; cell; min6 cells ... See more keywords