Role of Nonstatin Therapies for Low-Density Lipoprotein Cholesterol Lowering in Management of Atherosclerotic Cardiovascular Disease Risk.
Sign Up to like & getrecommendations! Published in 2017 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2016.4640
Abstract: MAJOR RECOMMENDATIONS: The Expert Consensus Panel made recommendations for 4 groups at risk for ASCVD who should already be receiving statin therapy. Guidance is provided on approaches to stressing statin adherence, intensifying lifestyle modifications, evaluating… read more here.
Keywords: reduction; risk; ldl; nonstatin therapies ... See more keywords
Smoking is a cause of amyotrophic lateral sclerosis. High low‐density lipoprotein cholesterol levels? Unsure
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25468
Abstract: Identifying mechanisms of neurodegenerative disease causation has long seemed to be beyond the reach of traditional epidemiological tools. Elucidating a plausible mechanism for initiation of amyotrophic lateral sclerosis (ALS) has appeared particularly elusive. The impression… read more here.
Keywords: cholesterol levels; ldl; cholesterol; amyotrophic lateral ... See more keywords
Genetically-Determined LDL Cholesterol and Risk of Subarachnoid Hemorrhage.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of neurology"
DOI: 10.1002/ana.26250
Abstract: OBJECTIVE We evaluated whether genetically-elevated Low-Density Lipoprotein Cholesterol (LDL-C) levels are associated with lower risk of intracranial aneurysms and subarachnoid hemorrhage (IA/SAH). METHODS We conducted a two-sample Mendelian Randomization (MR) study. Our primary analysis used… read more here.
Keywords: risk; ldl; cholesterol; subarachnoid hemorrhage ... See more keywords
Four-year HbA1c and LDL-cholesterol trajectories among individuals with mental disorders and newly developed type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2021 at "Brain and behavior"
DOI: 10.1002/brb3.2372
Abstract: The impact of different types of mental disorders on long-term glycemic and lipid trajectories following newly diagnosed type 2 diabetes (T2D) remains unknown. We used real-world clinical data in a population-based cohort to fill this… read more here.
Keywords: four year; ldl; hba1c; type diabetes ... See more keywords
A phase 1 study to evaluate the safety and LDL cholesterol–lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cardiology"
DOI: 10.1002/clc.22687
Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) downregulates low‐density lipoprotein (LDL) receptors, thereby leading to a rise in circulating LDL cholesterol (LDL‐C). RG7652 is a fully human monoclonal antibody against PCSK9. This placebo‐controlled, phase 1 ascending‐dose… read more here.
Keywords: ldl cholesterol; proprotein convertase; ldl; subtilisin kexin ... See more keywords
Dendrobine modulates autophagy to alleviate ox‐LDL‐induced oxidative stress and senescence in HUVECs
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21937
Abstract: Dendrobine has potential advantages in suppressing atherosclerosis (AS). FK506‐binding protein 1A (FKBP1A) is implicated in the regulation of autophagy, inflammation, and apoptosis. To reveal the mechanism by which dendrobine inhibits AS by modulating autophagy, oxidative… read more here.
Keywords: dendrobine; apoptosis; oxidative stress; senescence ... See more keywords
Low-density lipoprotein (LDL) and the risk of thrombotic events in essential thrombocythemia and polycythemia vera
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Hematology"
DOI: 10.1007/s00277-021-04431-0
Abstract: Dear Editor, With great interest we have read the recent article by Caocci et al. reporting that total cholesterol (TC) < 200 mg/ dL and low-density lipoprotein (LDL) < 70 mg/dL may be associated with… read more here.
Keywords: risk; density lipoprotein; ldl; lipoprotein ldl ... See more keywords
M1 Macrophages but Not M2 Macrophages Are Characterized by Upregulation of CRP Expression via Activation of NFκB: a Possible Role for Ox-LDL in Macrophage Polarization
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0793-8
Abstract: Arterial macrophages comprise a heterogeneous population: pro-inflammatory (M1) and anti-inflammatory (M2). Since C-reactive protein (CRP) is produced by macrophages in atherosclerotic lesions, understanding of CRP regulation in macrophages could be crucial to decipher inflammatory patterns… read more here.
Keywords: ldl; crp expression; macrophages macrophages; expression ... See more keywords
Up-regulation of PCSK9 gene expression and diminished level of LDL-receptor in rat liver as a potential cause of post-lipectomy hypercholesterolemia
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3484-8
Abstract: Studies designed to examine effects of fat mass reduction (including lipodystrophy and lipectomy) on human serum total and LDL-cholesterol concentrations are inconsistent. The purpose of this study was to examine effect of partial lipectomy in… read more here.
Keywords: lipectomy; mass; ldl; cholesterol ... See more keywords
A stricter control of low-density lipoprotein is necessary for thrombosis reduction in “lower thrombosis risk” patients with atrial fibrillation: a multicenter retrospective cohort study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-020-02110-x
Abstract: Patients with atrial fibrillation (AF) are associated with increased thrombotic events. Our previous case–control study showed low-density lipoprotein cholesterol (LDL-C) was an independent predictor of ischemic stroke in AF patients. To investigate the risks of… read more here.
Keywords: atrial fibrillation; risk; control; ldl ... See more keywords
Low LDL-C levels are associated with risk of mortality in a Chinese cohort study
Sign Up to like & getrecommendations! Published in 2021 at "Endocrine"
DOI: 10.1007/s12020-021-02746-6
Abstract: Although low-density lipoprotein cholesterol (LDL-C) has been considered as a risk factor of atherosclerotic cardiovascular disease, limited studies can be available to evaluate the association of LDL-C with risk of mortality in the general population.… read more here.
Keywords: risk; risk mortality; ldl; ldl levels ... See more keywords