PCSK9 Inhibitors, Statins, Low-Density Lipoprotein Cholesterol, Mevalonate Pathway, and Toxicity.
Sign Up to like & getrecommendations! Published in 2017 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2017.2727
Abstract: PCSK9 Inhibitors, Statins, Low-Density Lipoprotein Cholesterol, Mevalonate Pathway, and Toxicity To the Editor In a study by Koren et al,1 proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors exhibited potent and persistent long-term efficacy in reducing… read more here.
Keywords: pcsk9 inhibitors; ldl cholesterol; mevalonate pathway; cholesterol ... See more keywords
Association of Rare Protein-Truncating DNA Variants in APOB or PCSK9 With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2022.5271
Abstract: Importance Protein-truncating variants (PTVs) in apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9) are associated with significantly lower low-density lipoprotein (LDL) cholesterol concentrations. The association of these PTVs with coronary heart disease (CHD)… read more here.
Keywords: apob pcsk9; ldl cholesterol; cholesterol level; risk ... See more keywords
Cerivastatin for lowering lipids.
Sign Up to like & getrecommendations! Published in 2017 at "Cochrane Database of Systematic Reviews"
DOI: 10.1002/14651858.cd012501
Abstract: BACKGROUND: Cerivastatin was the most potent statin until it was withdrawn from the market due to a number of fatalities due to rhabdomyolysis, however, the dose-related magnitude of effect of cerivastatin on blood lipids is… read more here.
Keywords: ldl cholesterol; rosuvastatin; cholesterol; cerivastatin ... See more keywords
A phase 1 study to evaluate the safety and LDL cholesterol–lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cardiology"
DOI: 10.1002/clc.22687
Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) downregulates low‐density lipoprotein (LDL) receptors, thereby leading to a rise in circulating LDL cholesterol (LDL‐C). RG7652 is a fully human monoclonal antibody against PCSK9. This placebo‐controlled, phase 1 ascending‐dose… read more here.
Keywords: ldl cholesterol; proprotein convertase; ldl; subtilisin kexin ... See more keywords
LDL cholesterol promotes the proliferation of prostate and pancreatic cancer cells by activating the STAT3 pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30229
Abstract: Hypercholesterolemia has been found to be closely linked with a significant increase in both cancer incidence and mortality. However, the exact correlation between serum cholesterol levels and cancer has not been completely deciphered. Here we… read more here.
Keywords: cancer; proliferation; ldl cholesterol; prostate pancreatic ... See more keywords
[Lipid-lowering therapy in the elderly : Who profits from which target values?]
Sign Up to like & getrecommendations! Published in 2018 at "Herz"
DOI: 10.1007/s00059-018-4686-2
Abstract: Lowering low-density lipoprotein (LDL) cholesterol levels has been proven to reduce the incidence of cardiovascular and cerebrovascular events and mortality. So far recommendations have not provided information as to a meaningful duration of cholesterol-lowering therapy and… read more here.
Keywords: ldl cholesterol; lowering therapy; cholesterol lowering; target ... See more keywords
The lipid-lowering effect of once-daily soya drink fortified with phytosterols in normocholesterolaemic Chinese: a double-blind randomized controlled trial
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nutrition"
DOI: 10.1007/s00394-019-02119-w
Abstract: Purpose Phytosterols reduce intestinal cholesterol absorption and help to lower LDL-cholesterol. Many Chinese adults are lactose-intolerant and cannot tolerate bovine milk enriched with phytosterol. Soya-milk is a common beverage in Asia and it has beneficial… read more here.
Keywords: soya drink; ldl cholesterol; cholesterol; controlled trial ... See more keywords
LDL Cholesterol Reduction Variability with Different Types and Doses of Statins in Monotherapy or Combined with Ezetimibe. Results from the Spanish Arteriosclerosis Society Dyslipidaemia Registry
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-020-07137-z
Abstract: Low-density lipoprotein (LDL) cholesterol reduction by statin therapy is dose-dependent, varies among different statins, and has wide inter-individual variability. The present study aimed to compare mean LDL cholesterol reduction and its variability achieved with different… read more here.
Keywords: cholesterol reduction; cholesterol; combined ezetimibe; ldl cholesterol ... See more keywords
How controlled were dyslipidemias in a year of pandemic?
Sign Up to like & getrecommendations! Published in 2021 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2021.06.511
Abstract: Background and Aims: To describe and compare characteristics and metabolic control of a population with dyslipidemia prior to and during the COVID19 pandemic. Methods: We included all the patients with dyslipidemia followed at an Endocrinology… read more here.
Keywords: hdl cholesterol; ldl cholesterol; non hdl; cholesterol ... See more keywords
Elevated Plasma Levels of LDL Cholesterol Promote Dissecting Thoracic Aortic Aneurysms in Angiotensin II-Induced Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Annals of vascular surgery"
DOI: 10.1016/j.avsg.2017.10.006
Abstract: BACKGROUND Plasma low-density lipoprotein (LDL) cholesterol is implicated in abdominal aorta (AA) and aortic dissection (AD); however, its role in the pathogenesis of AA and AD, a disease with a high mortality rate, is unknown.… read more here.
Keywords: ldl cholesterol; cholesterol; formation; induced mice ... See more keywords
LDL-CHOLESTEROL, APOB100 KINETICS AND ATHEROSCLEROSIS IN LDLR-DEFICIENT YUCATAN MINIPIGS: A NEW MODEL FOR FAMILIAL HYPERCHOLESTEROLEMIA
Sign Up to like & getrecommendations! Published in 2017 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1016/j.cjca.2017.07.116
Abstract: Lack of animal models with human-like lipoprotein metabolism and pathology has hampered translational research in atherosclerosis. Recently, a model of familial hypercholesterolemia was developed i... read more here.
Keywords: ldl cholesterol; model familial; cholesterol apob100; apob100 kinetics ... See more keywords