The GLP‐1 receptor agonist liraglutide protects against oxidized LDL‐induced endothelial inflammation and dysfunction via KLF2
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2046
Abstract: Cardiovascular complications are the major causes of the mortality and morbidities in diabetic patients. The diabetic patients have an increased risk of developing atherosclerosis, which could lead to heart attack and stroke. Glucagon‐like peptide 1… read more here.
Keywords: glp receptor; ldl induced; klf2;
Foxc2 Alleviates Ox-LDL-Induced Lipid Accumulation, Inflammation, and Apoptosis of Macrophage via Regulating the Expression of Angptl2
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DOI: 10.1007/s10753-020-01217-w
Abstract: The present study aimed to investigate the role of Forkhead box protein C2 (Foxc2) in oxidized low-density lipoprotein (ox-LDL)-induced macrophages and identify the potential mechanisms. RAW264.7 cells, the murine macrophage cell line, were stimulated by… read more here.
Keywords: apoptosis; inflammation; angptl2; expression angptl2 ... See more keywords
Clematichinenoside AR Alleviates Foam Cell Formation and the Inflammatory Response in Ox-LDL-Induced RAW264.7 Cells by Activating Autophagy
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DOI: 10.1007/s10753-020-01375-x
Abstract: Foam cell formation and inflammation in macrophages contribute to the development of atherosclerosis (AS). Clematichinenoside AR (AR) is a major active ingredient extracted from the traditional Chinese herb Clematis chinensis and has potent pharmacological effects… read more here.
Keywords: cell formation; foam cell; formation; induced raw264 ... See more keywords
MiR-199a-3p Restrains Foaming and Inflammation by Regulating RUNX1 in Macrophages
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DOI: 10.1007/s12033-022-00484-2
Abstract: MiR-199a-3p was reported decreased in serum of coronary heart disease patients and human atherosclerotic plaques. This study aims to investigate the roles of miR-199a-3p in atherosclerosis (AS). AS was induced in ApoE−/− mice via high… read more here.
Keywords: mir 199a; raw264 cells; ldl induced; runx1 ... See more keywords
LncRNA XIST knockdown ameliorates oxidative low-density lipoprotein-induced endothelial cells injury by targeting miR-204-5p/TLR4
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biosciences"
DOI: 10.1007/s12038-020-0022-0
Abstract: Oxidative low-density lipoprotein (ox-LDL)-induced endothelial cell injury is a key contributor to atherosclerosis development. However, the role and mechanism of long noncoding RNA X-inactive specific transcript (XIST) in atherosclerosis remain largely unknown. The ox-LDL-induced human… read more here.
Keywords: xist; tlr4; mir 204; injury ... See more keywords
HDAC3 protects against atherosclerosis through inhibition of inflammation via the microRNA-19b/PPARγ/NF-κB axis.
Sign Up to like & getrecommendations! Published in 2021 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2021.02.013
Abstract: BACKGROUND AND AIMS Atherosclerosis (AS) is one of the leading causes of cardiovascular diseases. Studies have revealed critical roles of microRNAs (miRNAs) in the progression of AS. This study was conducted to elucidate the role… read more here.
Keywords: ppar; mir 19b; inflammation; hdac3 ... See more keywords
Overexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1α-dependent mitochondrial homeostasis in endothelial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114559
Abstract: Retinoid X receptor beta (RXRβ) has been poorly studied in atherosclerosis. The aim of the present study is to explore the function of RXRβ in oxidized low density lipoprotein (ox-LDL)-induced inflammation in endothelial cells and… read more here.
Keywords: overexpression; induced inflammation; ldl; endothelial cells ... See more keywords
The DPP‐4 inhibitor saxagliptin ameliorates ox‐LDL‐induced endothelial dysfunction by regulating AP‐1 and NF‐&kgr;B
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.01.008
Abstract: Abstract Diabetes‐associated cardiovascular complications are the leading cause of death for diabetic patients. Dipeptidyl peptidase 4 (DPP‐4) inhibitor agents, known as gliptins, are a class of potent anti‐glycemic agents developed to treat diabetes. Recently, gliptins… read more here.
Keywords: dpp inhibitor; adhesion; ldl induced; saxagliptin ... See more keywords
Oxytocin inhibits ox‐LDL‐induced adhesion of monocytic THP‐1 cells to human brain microvascular endothelial cells
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DOI: 10.1016/j.taap.2017.10.022
Abstract: &NA; The attachment of monocytes to human brain microvascular endothelial cells (HBMVEs) caused by oxidized low‐density lipoprotein (ox‐LDL) is associated with an early event and the pathological progression of cerebrovascular diseases. Oxytocin (OT) is a… read more here.
Keywords: thp; brain microvascular; ldl; human brain ... See more keywords
Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPARγ/CD36 signal pathway.
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DOI: 10.1016/j.taap.2021.115733
Abstract: The formation of fat-laden foam cells plays an important role in the initiation and progression of atherosclerosis (AS). Amentoflavone (AF) is found in various traditional Chinese medicines, such as , which are used to treat… read more here.
Keywords: accumulation; lipid accumulation; induced lipid; ppar cd36 ... See more keywords
Resveratrol protects against ox-LDL-induced endothelial dysfunction in atherosclerosis via depending on circ_0091822/miR-106b-5p-mediated upregulation of TLR4
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2093740
Abstract: Abstract Background Atherosclerosis (AS) is the most common inducer of cardiovascular diseases, and resveratrol (RSV) has played a protective function in the endothelial injury of AS. This study was to explore the molecular mechanism of… read more here.
Keywords: circ 0091822; mir 106b; tlr4; endothelial dysfunction ... See more keywords