Triglyceride-lowering LPL alleles combined with LDL-C-lowering alleles are associated with an additively improved lipoprotein profile.
Sign Up to like & getrecommendations! Published in 2021 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2021.04.015
Abstract: BACKGROUND AND AIMS Mendelian randomization studies have shown that triglyceride (TG)- lowering lipoprotein lipase (LPL) alleles and low-density lipoprotein-cholesterol (LDL-C)-lowering alleles have independent beneficial associations on cardiovascular disease (CVD) risk. We aimed to provide further… read more here.
Keywords: triglyceride lowering; ldl; lpl alleles; lowering alleles ... See more keywords
Bempedoic Acid: a cholesterol lowering agent with a novel mechanism of action
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2021.1901579
Abstract: ABSTRACT Introduction Dyslipidemia is a common condition that increases the risk of heart diseases and stroke. High levels of low-density lipoprotein-cholesterol (LDL-C) are correlated with a higher risk for heart disease. A drug class known… read more here.
Keywords: bempedoic acid; cholesterol; pharmacology; acid ... See more keywords
Low-density lipoprotein cholesterol targeting with pitavastatin + ezetimibe for patients with acute coronary syndrome and dyslipidaemia: the HIJ-PROPER study, a prospective, open-label, randomized trial
Sign Up to like & getrecommendations! Published in 2017 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehx162
Abstract: Abstract Aims To elucidate the effects of intensive LDL-C lowering treatment with a standard dose of statin and ezetimibe in patients with dyslipidaemia and high risk of coronary events, targeting LDL-C less than 70 mg/dL (1.8 mmol/L),… read more here.
Keywords: plus ezetimibe; trial; pitavastatin; standard ... See more keywords
Clinical implications of the log linear association between LDL-C lowering and cardiovascular risk reduction: Greatest benefits when LDL-C >100 mg/dl
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0240166
Abstract: Background The log linear association between on-treatment LDL-C levels and ASCVD events is amplified in higher risk patient subgroups of statin versus placebo trials. Objectives Update previous systematic review to evaluate how the log linear… read more here.
Keywords: risk; linear association; log linear; ldl lowering ... See more keywords
Lunasin Improves the LDL-C Lowering Efficacy of Simvastatin via Inhibiting PCSK9 Expression in Hepatocytes and ApoE−/− Mice
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24224140
Abstract: Statins are the most popular therapeutic drugs to lower plasma low density lipoprotein cholesterol (LDL-C) synthesis by competitively inhibiting hydroxyl-3-methyl-glutaryl-CoA (HMG-CoA) reductase and up-regulating the hepatic low density lipoprotein receptor (LDLR). However, the concomitant up-regulation… read more here.
Keywords: efficacy simvastatin; simvastatin; lowering efficacy; apoe mice ... See more keywords
LDL-Cholesterol Lowering of Plant Sterols and Stanols—Which Factors Influence Their Efficacy?
Sign Up to like & getrecommendations! Published in 2018 at "Nutrients"
DOI: 10.3390/nu10091262
Abstract: The LDL-cholesterol (LDL-C) lowering effect of plant sterols/stanols (PSS) is summarized in several meta-analyses showing a dose-response relationship with intakes of 1.5 to 3 g/day lowering LDL-C by 7.5% to 12%. This review summarizes evidence… read more here.
Keywords: sterols stanols; ldl cholesterol; plant sterols; ldl ... See more keywords
A First-in-Class Drug, Lomitapide, Tailored to Patients with Homozygous Familial Hypercholesterolemia is Just about Meeting with Good News to Them
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Atherosclerosis and Thrombosis"
DOI: 10.5551/jat.ed069
Abstract: A raised low-density lipoprotein (LDL) cholesterol (LDL-C) is one of the major risk factors for atherosclerotic cardiovascular disease (ASCVD) . Homozygous family hypercholesterolemia (HoFH) is a rare inherited disease characterized by markedly elevated levels of… read more here.
Keywords: hofh; hypercholesterolemia; ldl; target ... See more keywords
LDL-C–lowering therapies reduce major vascular events in patients aged ≥75 y
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Internal Medicine"
DOI: 10.7326/acpj202104200-038
Abstract: SOURCE CITATION Gencer B, Marston NA, Im K, et al. Efficacy and safety of lowering LDL cholesterol in older patients: a systematic review and meta-analysis of randomised controlled trials. Lancet. 2020;396:1637-43. 33186535. read more here.
Keywords: ldl lowering; vascular events; reduce major; lowering therapies ... See more keywords