Effect of vinyl chloride exposure on cardiometabolic toxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology"
DOI: 10.1002/tox.23394
Abstract: Vinyl chloride (VC) is an organochlorine mainly used to manufacture its polymer polyvinyl chloride, which is extensively used in the manufacturing of consumer products. Recent studies suggest that chronic low dose VC exposure affects glucose… read more here.
Keywords: ldl receptor; inflammation; exposure; mice ... See more keywords
Phenotypic characterization and predictive analysis of p.Asp47Asn LDL receptor mutation associated with Familial Hypercholesterolemia in a Chilean population.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2021.01.002
Abstract: BACKGROUND Familial hypercholesterolemia (FH) is an inherited disorder mainly caused by mutations in the LDL receptor (LDL-R) and characterized by elevation of low-density lipoprotein cholesterol (LDL-C) levels and premature cardiovascular disease. OBJECTIVE In this study,… read more here.
Keywords: familial hypercholesterolemia; asp47asn ldl; ldl receptor; ldl ... See more keywords
PCSK9 stimulates Syk, PKCδ, and NF-κB, leading to atherosclerosis progression independently of LDL receptor
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-46336-2
Abstract: Proprotein convertase subtilisin/kexin type-9 (PCSK9) binds to and degrades low-density lipoprotein (LDL) receptor, leading to increase of LDL cholesterol in blood. Its blockers have emerged as promising therapeutics for cardiovascular diseases. Here we show that… read more here.
Keywords: receptor; cap1; syk pkc; independently ldl ... See more keywords
LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49301-1
Abstract: Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes… read more here.
Keywords: receptor; receptor alphavirus; ldl receptor; entry structural ... See more keywords
Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.121.320056
Abstract: Background: Activated macrophages contribute to the pathogenesis of vascular disease. Vein graft failure is a major clinical problem with limited therapeutic options. PCSK9 (proprotein convertase subtilisin/kexin 9) increases low-density lipoprotein (LDL)-cholesterol levels via LDL receptor… read more here.
Keywords: macrophage activation; vein graft; ldl receptor; pcsk9 ... See more keywords
Hypolipidemic Drugs and Diabetes Mellitus—Mechanisms and Data From Genetic Trials
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cardiovascular Pharmacology and Therapeutics"
DOI: 10.1177/1074248418757011
Abstract: Clinical trials and meta-analyses have shown that statins can dose dependently increase the incidence of new-onset diabetes mellitus (DM) especially in patients with underlying abnormalities of carbohydrate homeostasis. Mendelian randomization studies support these findings since… read more here.
Keywords: ldl receptor; receptor expression; target; diabetes mellitus ... See more keywords
Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish[S]
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Lipid Research"
DOI: 10.1194/jlr.d081521
Abstract: Elevated plasma LDL cholesterol is the dominant risk factor for the development of atherosclerosis and cardiovascular disease. Deficiency in the LDL receptor (LDLR) is a major cause of familial hypercholesterolemia in humans, and the LDLR… read more here.
Keywords: ldl receptor; accumulation; hypercholesterolemia; mutant zebrafish ... See more keywords
USP16 Regulates the Stability and Function of LDL receptor by Deubiquitination.
Sign Up to like & getrecommendations! Published in 2020 at "International heart journal"
DOI: 10.1536/ihj.20-043
Abstract: Low-density lipoprotein (LDL) particles are known to be atherogenic agents in coronary artery diseases. They adjust to other electronegative forms and can be the subject for the enhancement of inflammatory events in vessel subendothelial spaces.… read more here.
Keywords: ldl receptor; regulates stability; usp16 regulates; receptor ... See more keywords