Acute Myelogenous Leukemia Cells Secrete Factors that Stimulate Cellular LDL Uptake via Autocrine and Paracrine Mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Lipids"
DOI: 10.1007/s11745-017-4256-z
Abstract: Leukemic cells isolated from most patients with acute myelogenous leukemia (AML) have higher low density lipoprotein (LDL) uptake than normal mononuclear blood cells. Little is known, however, about the mechanism behind the elevated LDL uptake.… read more here.
Keywords: ldl uptake; ldl degradation; cells secrete; aml cells ... See more keywords
In vitro selection generates RNA aptamer that antagonizes PCSK9-LDLR interaction and recovers cellular LDL uptake.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2020.10.009
Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) induces low-density lipoprotein (LDL)-receptor (LDLR) degradation, increasing plasma LDL-cholesterol levels and causing hypercholesterolemia. Therefore, inhibition of PCSK9-LDLR interaction is an attractive therapeutic target for hypercholesterolemia treatment. In this study,… read more here.
Keywords: rna aptamer; ldl uptake; ldlr interaction; pcsk9 ldlr ... See more keywords
Unconjugated p-cresol activates macrophage macropinocytosis leading to increased LDL uptake
Sign Up to like & getrecommendations! Published in 2021 at "JCI Insight"
DOI: 10.1172/jci.insight.144410
Abstract: Patients with chronic kidney disease (CKD) and end-stage renal disease suffer from increased cardiovascular events and cardiac mortality. Prior studies have demonstrated that a portion of this enhanced risk can be attributed to the accumulation… read more here.
Keywords: unconjugated cresol; ldl uptake; macropinocytosis; cresol activates ... See more keywords
Genome-scale CRISPR screening for modifiers of cellular LDL uptake.
Sign Up to like & getrecommendations! Published in 2021 at "PLoS genetics"
DOI: 10.1371/journal.pgen.1009285
Abstract: Hypercholesterolemia is a causal and modifiable risk factor for atherosclerotic cardiovascular disease. A critical pathway regulating cholesterol homeostasis involves the receptor-mediated endocytosis of low-density lipoproteins into hepatocytes, mediated by the LDL receptor. We applied genome-scale… read more here.
Keywords: genome scale; ldl uptake; scale crispr; cellular ldl ... See more keywords