Ultramorphological analysis of plaque advancement and cholesterol crystal formation in Ldlr knockout mouse atherosclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2019.05.029
Abstract: BACKGOUND AND AIMS The low-density lipoprotein receptor-deficient (Ldlr-/-) mouse has been utilized by cardiovascular researchers for more than two decades to study atherosclerosis. However, there has not yet been a systematic effort to document the… read more here.
Keywords: cholesterol; atherosclerosis ultramorphological; plaque; ldlr ... See more keywords
A systematic review of LDLR, PCSK9, and APOB variants in Asia.
Sign Up to like & getrecommendations! Published in 2020 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2020.05.004
Abstract: BACKGROUND AND AIMS Genetic identification is a public health care concern for management of familial hypercholesterolemia (FH) associated cardiovascular morbidity and mortality. This study presents the spectrum and distribution of LDLR, APOB, PCSK9 gene mutations… read more here.
Keywords: apob; systematic review; review ldlr; pcsk9 ... See more keywords
LDLR variants functional characterization: Contribution to variant classification.
Sign Up to like & getrecommendations! Published in 2021 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2021.06.001
Abstract: BACKGROUND AND AIMS Familial hypercholesterolaemia (FH) is an autosomal disorder of lipid metabolism presenting with increased cardiovascular risk. LDLR mutations are the cause of disease in 90% of the cases but functional studies have only… read more here.
Keywords: classification; variant classification; functional characterization; ldlr ... See more keywords
Identification of a PCSK9-LDLR disruptor peptide with in vivo function.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.08.012
Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promoting hepatic LDL receptor (LDLR) degradation. Therapeutic antibodies that disrupt PCSK9-LDLR binding reduce LDL-C concentrations and cardiovascular disease risk. The epidermal… read more here.
Keywords: ldlr disruptor; pcsk9; pcsk9 ldlr; function ... See more keywords
Clocks and Cholesterol: Co-agonists in Cardiovascular Disease?
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.05.021
Abstract: Circadian (i.e. 24-hour) rhythms regulate much of our physiology, a under HFD compared to Ldlr −/− single mutants under entrained regulation that is supported by rhythmicity in individual cells of the body. Maintenance of cellular… read more here.
Keywords: density lipoprotein; disease; low density; mice ... See more keywords
The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.07.010
Abstract: Objective Insulin resistance is associated with impaired receptor dependent hepatic uptake of triglyceride-rich lipoproteins (TRL), promoting hypertriglyceridemia and atherosclerosis. Next to low-density lipoprotein (LDL) receptor (LDLR) and syndecan-1, the LDLR-related protein 1 (LRP1) stimulated by… read more here.
Keywords: protein; pid1; endocytosis postprandial; microscopy ... See more keywords
LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101230
Abstract: Objective Adaptive rewiring of cancer energy metabolism has received increasing attention. By binding with LDLs, LDLRs make most of the circulating cholesterol available for cells to utilize. However, it remains unclear how LDLR works in… read more here.
Keywords: mek erk; intracellular cholesterol; cholesterol synthesis; cholesterol ... See more keywords
Testosterone Deficiency Promotes Hypercholesteremia and Attenuates Cholesterol Liver Uptake via AR/PCSK9/LDLR Pathways
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Endocrinology"
DOI: 10.1155/2022/7989751
Abstract: Background Testosterone deficiency is reportedly correlated with an elevation of cholesterol in plasma, but the mechanism remains unclear. Our objective was to investigate the effects of testosterone deficiency on cholesterol metabolism and the corresponding molecular… read more here.
Keywords: pcsk9; testosterone deficiency; testosterone; cholesterol ... See more keywords
Leu22_Leu23 Duplication at the Signal Peptide of PCSK9 Promotes Intracellular Degradation of LDLr and Autosomal Dominant Hypercholesterolemia
Sign Up to like & getrecommendations! Published in 2022 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.315499
Abstract: Background: PCSK9 (Proprotein convertase subtilisin/kexin type 9) regulates LDL-C (low-density lipoprotein cholesterol) metabolism by targeting LDLr (LDL receptor) for lysosomal degradation. PCSK9 gain-of-function variants cause autosomal dominant hypercholesterolemia by reducing LDLr levels, the D374Y variant… read more here.
Keywords: hypercholesterolemia; pcsk9; signal peptide; degradation ... See more keywords
A novel indel variant in LDLR responsible for familial hypercholesterolemia in a Chinese family
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0189316
Abstract: Familial hypercholesterolemia (FH) is an inherited disorder characterized by elevation of serum cholesterol bound to low-density lipoprotein. Mutations in LDLR are the major factors responsible for FH. In this study, we recruited a four-generation Chinese… read more here.
Keywords: hypercholesterolemia; chinese family; familial hypercholesterolemia; indel ... See more keywords
Effects of statins on the inducible degrader of low-density lipoprotein receptor in familial hypercholesterolemia
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine Connections"
DOI: 10.1530/ec-22-0019
Abstract: The inducible degrader of low-density lipoprotein receptor (IDOL) is an E3 ubiquitin ligase involved in the post-transcriptional regulation of LDL receptor (LDLR). Statins lower plasma LDL by activating transcription of hepatic LDLR expression, and we… read more here.
Keywords: inducible degrader; level; expression; receptor ... See more keywords