Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats.
Sign Up to like & getrecommendations! Published in 2018 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2018.02.015
Abstract: BACKGROUND AND AIMS Low-density lipoprotein receptor (Ldlr) and apolipoprotein E (Apoe) knockout (KO) mice have been widely used as animal models of atherosclerosis. However, data suggested that it is difficult to develop typical atherosclerosis in… read more here.
Keywords: typical atherosclerosis; atherosclerosis; atherosclerosis rats; ldlr apoe ... See more keywords
Additive Effect of APOE Rare Variants on the Phenotype of Familial Hypercholesterolemia.
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, thrombosis, and vascular biology"
DOI: 10.1161/atvbaha.123.319146
Abstract: BACKGROUND Autosomal dominant hypercholesterolemia (ADH) is due to deleterious variants in LDLR, APOB, or PCSK9 genes. Double heterozygote for these genes induces a more severe phenotype. More recently, a new causative variant of heterozygous ADH… read more here.
Keywords: familial hypercholesterolemia; additive effect; apoe; ldlr apoe ... See more keywords
Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system
Sign Up to like & getrecommendations! Published in 2019 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-019-1013-8
Abstract: ObjectiveTo generate novel rabbit models with a large-fragment deletion of either LDL receptor (LDLR) and/or apolipoprotein (apoE) genes for the study of hyperlipidemic and atherosclerosis.MethodsCRISPR/Cas9 system directed by a multiple sgRNAs system was used in… read more here.
Keywords: system; ldlr apoe; rabbit models; multiple sgrnas ... See more keywords