In vitro selection generates RNA aptamer that antagonizes PCSK9-LDLR interaction and recovers cellular LDL uptake.
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DOI: 10.1016/j.jbiosc.2020.10.009
Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) induces low-density lipoprotein (LDL)-receptor (LDLR) degradation, increasing plasma LDL-cholesterol levels and causing hypercholesterolemia. Therefore, inhibition of PCSK9-LDLR interaction is an attractive therapeutic target for hypercholesterolemia treatment. In this study,… read more here.
Keywords: rna aptamer; ldl uptake; ldlr interaction; pcsk9 ldlr ... See more keywords