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   Articles with "ldlr mice" as a keyword



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Gut microbiota dysbiosis augments atherosclerosis in LDLR-/- mice.

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recommendations! Published in 2017 at "Atherosclerosis"

DOI: 10.1016/j.atherosclerosis.2017.06.316

Abstract: Aim: In recent years the gut microbiome has been recognized as an important participant in the etiology of obesity and -associated comorbidities. Moreover, recent studies have implicated an involvement of the gut microbiota in both… read more here.

Keywords: ldlr mice; gut microbiota; mice;
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Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr-/- mice.

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recommendations! Published in 2017 at "Atherosclerosis"

DOI: 10.1016/j.atherosclerosis.2017.10.009

Abstract: BACKGROUND AND AIMS Altered metabolism is an important regulator of macrophage (MΦ) phenotype, which contributes to inflammatory diseases such as atherosclerosis. Broadly, pro-inflammatory, classically-activated MΦs (CAM) are glycolytic while alternatively-activated MΦs (AAM) oxidize fatty acids,… read more here.

Keywords: lack myeloid; ldlr mice; mice; lesion ... See more keywords
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Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3.

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recommendations! Published in 2018 at "Atherosclerosis"

DOI: 10.1016/j.atherosclerosis.2017.12.025

Abstract: BACKGROUND AND AIMS Recent in vitro studies have showed that in macrophages, deletion of the non-selective Ca2+-permeable channel TRPC3 impairs expression of the osteogenic protein BMP-2. The pathophysiological relevance of this effect in atherosclerotic plaque calcification… read more here.

Keywords: ldlr mice; trpc3; mice macrophage; calcification ... See more keywords
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Bidirectional effects of IL-10+ regulatory B cells in Ldlr-/- mice.

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recommendations! Published in 2019 at "Atherosclerosis"

DOI: 10.1016/j.atherosclerosis.2018.11.019

Abstract: BACKGROUND AND AIMS Limiting the pro-inflammatory immune response is critical for the treatment of atherosclerosis. Regulatory B cells (Bregs) can modulate the immune response through interleukin-10 (IL-10). Current data regarding Bregs and atherosclerosis is scarce… read more here.

Keywords: ldlr mice; bidirectional effects; cells atherosclerosis; regulatory cells ... See more keywords
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Early rescue of lymphatic function limits atherosclerosis progression in Ldlr-/- mice.

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recommendations! Published in 2019 at "Atherosclerosis"

DOI: 10.1016/j.atherosclerosis.2019.01.031

Abstract: BACKGROUND AND AIMS Our previous data showed that lymphatic function impairment occurs before the onset of atherosclerosis in mice and is precociously associated with a defect in the propelling capacity of the collecting lymphatic vessels.… read more here.

Keywords: ldlr mice; lymphatic function; collecting lymphatic; progression ... See more keywords
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Naringenin enhances the regression of atherosclerosis induced by a chow diet in Ldlr-/- mice.

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recommendations! Published in 2019 at "Atherosclerosis"

DOI: 10.1016/j.atherosclerosis.2019.05.009

Abstract: BACKGROUND AND AIMS Naringenin is a citrus-derived flavonoid with lipid-lowering and insulin-sensitizing effects leading to athero-protection in Ldlr-/- mice fed a high-fat diet. However, the ability of naringenin to promote atherosclerosis regression is unknown. In… read more here.

Keywords: ldlr mice; regression; chow diet; mice ... See more keywords
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Effect of combining aspirin and rivaroxaban on atherosclerosis in mice.

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recommendations! Published in 2022 at "Atherosclerosis"

DOI: 10.1016/j.atherosclerosis.2022.02.010

Abstract: BACKGROUND AND AIMS The platelet inhibitor aspirin reduces inflammation and atherosclerosis in both apolipoprotein E deficient (apoE-/-) mice and low-density lipoprotein receptor deficient (Ldlr-/-) mice. Similarly, the factor Xa inhibitor rivaroxaban reduces atherosclerosis in both… read more here.

Keywords: mice; atherosclerosis; ldlr mice; atherosclerosis mice ... See more keywords

Knockdown of Herp alleviates hyperhomocysteinemia mediated atherosclerosis through the inhibition of vascular smooth muscle cell phenotype switching.

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recommendations! Published in 2018 at "International journal of cardiology"

DOI: 10.1016/j.ijcard.2018.07.043

Abstract: BACKGROUND Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a key role in atherosclerosis. We aimed to investigate whether Homocysteine-responsive endoplasmic reticulum protein (Herp) was involved in VSMC phenotypic switching and affected atheroprogression. METHODS… read more here.

Keywords: ldlr mice; herp; inhibition; phenotypic switching ... See more keywords
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Effects of a single bout of strenuous exercise on platelet activation in female ApoE/LDLR−/− mice

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recommendations! Published in 2017 at "Platelets"

DOI: 10.1080/09537104.2016.1254764

Abstract: Abstract Strenuous physical exercise leads to platelet activation that is normally counterbalanced by the production of endothelium-derived anti-platelet mediators, including prostacyclin (PGI2) and nitric oxide (NO). However, in the case of endothelial dysfunction, e.g. in… read more here.

Keywords: ldlr mice; exercise; apoe ldlr; activation ... See more keywords
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Red wine consumption mitigates the cognitive impairments in low-density lipoprotein receptor knockout (LDLr−/−) mice

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recommendations! Published in 2020 at "Nutritional Neuroscience"

DOI: 10.1080/1028415x.2019.1704472

Abstract: ABSTRACT Although the benefits of moderate intake of red wine in decreasing incidence of cardiovascular diseases associated to hypercholesterolemia are well recognized, there are still widespread misconceptions about its effects on the hypercholesterolemia-related cognitive impairments.… read more here.

Keywords: consumption; cognitive impairments; red wine; wine ... See more keywords
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Deficiency of inactive rhomboid protein 2 (iRhom2) attenuates diet-induced hyperlipidemia and early atherogenesis.

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recommendations! Published in 2021 at "Cardiovascular research"

DOI: 10.1093/cvr/cvab041

Abstract: AIMS Atherosclerosis is a chronic inflammatory disease of the arterial vessel wall and anti-inflammatory treatment strategies are currently pursued to lower cardiovascular disease burden. Modulation of recently discovered inactive rhomboid protein 2 (iRhom2) attenuates shedding… read more here.

Keywords: ldlr mice; diet induced; irhom2; irhom2 attenuates ... See more keywords