Activity‐Directed Synthesis: A Flexible Approach for Lead Generation
Sign Up to like & getrecommendations! Published in 2020 at "Chemmedchem"
DOI: 10.1002/cmdc.202000524
Abstract: Activity‐directed synthesis (ADS) is a structure‐blind, functional‐driven molecular discovery approach. In this Concept, four case studies highlight the general applicability of ADS and showcase its flexibility to support different medicinal chemistry strategies. ADS deliberately harnesses… read more here.
Keywords: activity directed; lead generation; directed synthesis; approach ... See more keywords
New Modalities, Technologies, and Partnerships in Probe and Lead Generation: Enabling a Mode-of-Action Centric Paradigm.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00378
Abstract: With the rise of novel biology and high potential target identification technologies originating from advances in genomics, medicinal chemists are progressively facing targets of increasing complexity and often unprecedented. Novel hit finding technologies, combined with… read more here.
Keywords: probe lead; lead generation; action centric; mode action ... See more keywords
A snapshot of lead-generation strategies
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Drug Discovery"
DOI: 10.1038/nrd.2018.129
Abstract: Antibiotic advocates have been steadily building the case for pull incentives as a means of offsetting the challenging economics of antibiotic development. The Review on Antimicrobial Resistance, commissioned by the UK government and chaired by… read more here.
Keywords: lead generation; economics; generation strategies; snapshot lead ... See more keywords
Dual-acting of Hybrid Compounds - A New Dawn in the Discovery of Multi-target Drugs: Lead Generation Approaches.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026616666160927151144
Abstract: Finding high quality beginning compounds is a critical job at the start of the lead generation stage for multi-target drug discovery (MTDD). Designing hybrid compounds as selective multitarget chemical entity is a challenge, opportunity, and… read more here.
Keywords: lead generation; generation; discovery; hybrid compounds ... See more keywords