A New Lead Identification Strategy: Screening an sp3‐rich and Lead‐like Compound Library Composed of 7‐Azanorbornane Derivatives
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900398
Abstract: Although the advantages of sp3‐rich, sterically complicated molecules in drug development have been pointed out, modern screening libraries are filled with planar, sp2‐rich components. Compounds that are sp3‐rich are difficult to synthesize, and thus we… read more here.
Keywords: sp3; lead identification; lead like; sp3 rich ... See more keywords
A systematic multicellular spheroids screening approach lead to the identification of antineoplastic activity in three different plant extracts from the Egyptian flora
Sign Up to like & getrecommendations! Published in 2017 at "journal of applied pharmaceutical science"
DOI: 10.7324/japs.2017.70603
Abstract: Developing natural products as potential antineoplastic drugs is a meticulous process involving both compound isolation and biological testing. Many studies are based on primary screening using tum ... read more here.
Keywords: spheroids screening; screening approach; systematic multicellular; lead identification ... See more keywords