A New Lead Identification Strategy: Screening an sp3‐rich and Lead‐like Compound Library Composed of 7‐Azanorbornane Derivatives
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900398
Abstract: Although the advantages of sp3‐rich, sterically complicated molecules in drug development have been pointed out, modern screening libraries are filled with planar, sp2‐rich components. Compounds that are sp3‐rich are difficult to synthesize, and thus we… read more here.
Keywords: sp3; lead identification; lead like; sp3 rich ... See more keywords
Tailoring a lead-like compound targeting multiple G-quadruplex structures.
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DOI: 10.1016/j.ejmech.2018.11.058
Abstract: A focused library of analogs of a lead-like G-quadruplex (G4) targeting compound (4), sharing a furobenzoxazine naphthoquinone core and differing for the pendant groups on the N-atom of the oxazine ring, has been here analyzed… read more here.
Keywords: tailoring lead; targeting multiple; like compound; lead like ... See more keywords
Build–Couple–Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity
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DOI: 10.1021/acs.jmedchem.2c00897
Abstract: High-throughput screening provides one of the most common ways of finding hit compounds. Lead-like libraries, in particular, provide hits with compatible functional groups and vectors for structural elaboration and physical properties suitable for optimization. Library… read more here.
Keywords: lead like; couple transform; synthesis; diversity ... See more keywords
Lead-like Drugs: A Perspective.
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DOI: 10.1021/acs.jmedchem.8b00407
Abstract: Lead-like drugs, or drugs below molecular weight 300, are an important and sometimes overlooked component of the current pharmacopeia and contemporary medicinal chemistry practice. To examine the recent state-of-the-art in lead-like drug discovery, we surveyed… read more here.
Keywords: low molecular; chemistry; lead like; molecular weight ... See more keywords
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
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DOI: 10.1021/acschembio.2c00234
Abstract: Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed the location of allosteric binding sites and opened new opportunities for the discovery of novel modulators. In this work, molecular docking screens for allosteric… read more here.
Keywords: lead like; glutamate receptor; metabotropic glutamate; allosteric modulators ... See more keywords