Mitogen activated protein kinase-1 and cell division control protein-42 are putative targets for the binding of novel natural lead molecules: a therapeutic intervention against Candida albicans
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1682053
Abstract: Abstract Candida albicans, fungal yeast causes several lethal infections in immune-suppressed patients and recently emerged as drug-resistant pathogens worldwide. The present study aimed to screen putative drug targets of Candia albicans and to study the… read more here.
Keywords: lead molecules; activated protein; drug; protein kinase ... See more keywords
Virtual screening of natural products inspired in-house library to discover potential lead molecules against the SARS-CoV-2 main protease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2027271
Abstract: Abstract SARS-CoV-2, a new coronavirus emerged in 2019, causing a global healthcare epidemic. Although a variety of drug targets have been identified as potential antiviral therapies, and effective candidate against SARS-CoV-2 remains elusive. One of… read more here.
Keywords: house; lead molecules; protease; cov main ... See more keywords
Significance of chalcone synthons as lead molecules in anticancer drug discovery.
Sign Up to like & getrecommendations! Published in 2021 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520621666210910084829
Abstract: read more here.
Keywords: significance chalcone; chalcone synthons; molecules anticancer; lead molecules ... See more keywords
Structural similarities between SARS-CoV2 3CLpro and other viral proteases suggest potential lead molecules for developing broad spectrum antivirals
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.948553
Abstract: Considering the significant impact of the recent COVID-19 outbreak, development of broad-spectrum antivirals is a high priority goal to prevent future global pandemics. Antiviral development processes generally emphasize targeting a specific protein from a particular… read more here.
Keywords: lead molecules; protease; cov2 3clpro; spectrum antivirals ... See more keywords
Identifying the Novel Inhibitors Against the Mycolic Acid Biosynthesis Pathway Target “mtFabH” of Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.818714
Abstract: Mycolic acids are the key constituents of mycobacterial cell wall, which protect the bacteria from antibiotic susceptibility, helping to subvert and escape from the host immune system. Thus, the enzymes involved in regulating and biosynthesis… read more here.
Keywords: mycobacterium tuberculosis; biosynthesis; lead molecules; mycolic acid ... See more keywords
Identification of Anticancer Lead Molecules against PRR11 Protein Target with Combination of Protein Modelling Through Threading Approach, Structure Based Chemical Screening of ZINC Database and Pharmacokinetic Properties
Sign Up to like & getrecommendations! Published in 2018 at "Indian Journal of Pharmaceutical Education and Research"
DOI: 10.5530/ijper.52.3.44
Abstract: PRR11 is a cell cycle regulator involved in pathogenesis of cancer. Therapeutically it has been identified as target to inhibit cancer growth. In this study, we employed in silico strategies for determining 3D structure of… read more here.
Keywords: pharmacokinetic properties; zinc database; prr11; lead molecules ... See more keywords