Syntheses and in vitro evaluation of new S1PR1 compounds and initial evaluation of a lead F-18 radiotracer in rodents.
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DOI: 10.1016/j.ejmech.2018.03.035
Abstract: Thirteen new sphingosine-1-phosphate receptor 1 (S1PR1) ligands were designed and synthesized by replacing azetidine-3-carboxylic acid moiety of compound 4 with new polar groups. The in vitro binding potency of these new analogs toward S1PR1 was determined.… read more here.
Keywords: lead radiotracer; 18f 12b; evaluation; s1pr1 ... See more keywords