Photoactivatable substrates for systematic study of the impact of an extracellular matrix ligand on appearance of leader cells in collective cell migration.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.03.045
Abstract: Epithelial cells migrate as multicellular units. The directionality and speed of these units are determined by actively moving leader cells. It is important to understand how external cues affect the appearance of these leader cells… read more here.
Keywords: leader; leader cells; geometry; appearance leader ... See more keywords
Intraflagellar transport 20 promotes collective cancer cell invasion by regulating polarized organization of Golgi‐associated microtubules
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.13970
Abstract: Collective invasion is an important strategy of cancers of epithelial origin, including colorectal cancer (CRC), to infiltrate efficiently into local tissues as collective cell groups. Within the groups, cells at the invasive front, called leader… read more here.
Keywords: invasion; intraflagellar transport; golgi; leader cells ... See more keywords
Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aaz6197
Abstract: Specialized leader cells use stable filopodia to create linear fibronectin tracks to promote collective cancer invasion. Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse, yet remains largely underexplored in invasion and metastasis. Here,… read more here.
Keywords: invasion; leader cells; collective invasion; fibronectin micropatterning ... See more keywords
Effect of heterogeneous substrate adhesivity of follower cells on speed and tension profile of leader cells in primary keratocyte collective cell migration
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.058893
Abstract: ABSTRACT In single keratocyte motility, membrane tension is reported to be high at cell-fronts and believed to establish front coherence. To understand role of membrane mechanics in collective cell migration, we study membrane height fluctuations… read more here.
Keywords: cell; collective cell; leader cells; tension ... See more keywords
The Pro-fibrotic Response of Mesenchymal Leader Cells to Lens Wounding Involves Hyaluronic Acid, Its Receptor RHAMM, and Vimentin
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.862423
Abstract: Hyaluronic Acid/Hyaluronan (HA) is a major component of the provisional matrix deposited by cells post-wounding with roles both in regulating cell migration to repair a wound and in promoting a fibrotic outcome to wounding. Both… read more here.
Keywords: post; rhamm; mesenchymal leader; leader ... See more keywords