A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing
Sign Up to like & getrecommendations! Published in 2019 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2019.04.001
Abstract: Infections with parasitic nematodes are among the most significant of the neglected tropical diseases affecting about a billion people living mainly in tropical regions with low economic activity. The most effective current strategy to control… read more here.
Keywords: leader trans; spliced leader; anthelmintic drugs; trans splicing ... See more keywords
An in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assembly
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx500
Abstract: Abstract Spliced leader (SL) trans-splicing is a critical element of gene expression in a number of eukaryotic groups. This process is arguably best understood in nematodes, where biochemical and molecular studies in Caenorhabditis elegans and… read more here.
Keywords: leader trans; spliced leader; vivo genetic; role ... See more keywords