Akinesia and freezing caused by Na+ leak‐current channel (NALCN) deficiency corrected by pharmacological inhibition of K+ channels and gap junctions
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24119
Abstract: The Na+ leak‐current channel (NALCN) regulates locomotion, respiration, and intellectual development. Previous work highlighted striking similarities between characteristic movement phenotypes of NALCN‐deficient animals (Drosophila and Caenorhabditis elegans) and the major symptoms of Parkinson's disease and… read more here.
Keywords: gap junctions; channels gap; channel nalcn; leak current ... See more keywords
Na+ leak-current channel (NALCN) at the junction of motor and neuropsychiatric symptoms in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-021-02348-6
Abstract: Parkinson’s disease (PD) is a debilitating movement disorder often accompanied by neuropsychiatric symptoms that stem from the loss of dopaminergic function in the basal ganglia and altered neurotransmission more generally. Akinesia, postural instability, tremors and… read more here.
Keywords: motor neuropsychiatric; neuropsychiatric symptoms; motor; parkinson disease ... See more keywords
A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer
Sign Up to like & getrecommendations! Published in 2020 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.15968.1
Abstract: Automated patch-clamp platforms are widely used and vital tools in both academia and industry to enable high-throughput studies such as drug screening. A leak current to ground occurs whenever the seal between a pipette and… read more here.
Keywords: patch clamp; time dependent; leak current;