Neonatal infection produces significant changes in immune function with no associated learning deficits in juvenile rats
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22512
Abstract: The current experiments examined the impact of early‐life immune activation and a subsequent mild immune challenge with lipopolysaccharide (LPS; 25µg/kg) on hippocampal‐dependent learning, proinflammatory cytokine expression in the brain, and peripheral immune function in juvenile… read more here.
Keywords: infection; expression; juvenile; learning deficits ... See more keywords
Visual discrimination and inhibitory control deficits in mouse models of Down syndrome: A pilot study using rodent touchscreen technology
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25160
Abstract: Several non‐verbal cognitive and behavioral tests have been developed to assess learning deficits in humans with Down syndrome (DS). Here we used rodent touchscreen paradigms in adult male mice to investigate visual discrimination (VD) learning… read more here.
Keywords: rodent touchscreen; visual discrimination; inhibitory control; learning deficits ... See more keywords
Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.50895
Abstract: We previously showed that NUDT21-spanning copy-number variations (CNVs) are associated with intellectual disability (Gennarino et al., 2015). However, the patients’ CNVs also included other genes. To determine if reduced NUDT21 function alone can cause disease,… read more here.
Keywords: cfim25; intellectual disability; partial loss; learning deficits ... See more keywords