Design and Synthesis of Galactosylated Bifurcated Ligands with Nanomolar Affinity for Lectin LecA from Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700154
Abstract: Lectin A (LecA) from Pseudomonas aeruginosa is an established virulence factor. Glycoclusters that target LecA and are able to compete with human glycoconjugates present on epithelial cells are promising candidates to treat P. aeruginosa infection. A family… read more here.
Keywords: lectin leca; pseudomonas aeruginosa; affinity; leca pseudomonas ... See more keywords
Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2020 at "Glycobiology"
DOI: 10.1093/glycob/cwaa057
Abstract: Abstract The carbohydrate-binding protein LecA (PA-IL) from Pseudomonas aeruginosa plays an important role in the formation of biofilms in chronic infections. Development of inhibitors to disrupt LecA-mediated biofilms is desired but it is limited to… read more here.
Keywords: pseudomonas aeruginosa; observed 19f; leca pseudomonas; protein observed ... See more keywords